Evidence map›Paper›PMID 38687799›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Functional overlap between the mammalian

Vi T Tang, Jie Xiang, Zhimin Chen, Joseph McCormick, Prabhodh S Abbineni, Xiao-Wei Chen, Mark Hoenerhoff, Brian T Emmer, Rami Khoriaty, Jiandie D Lin and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Paralogs of thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Genetics of hemostasis: from bedside to bench and back again.The Journal of clinical investigation · 2024
    Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Vi T TangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.
Jie Xiang *Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Zhimin ChenLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-4241-7122
Joseph McCormickLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.
Prabhodh S AbbineniLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-9700-0044
Xiao-Wei ChenState Key Laboratory of Membrane Biology, Peking University, Beijing 100871, China.ORCID 0000-0001-6466-6248
Mark HoenerhoffUnit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48109.
Brian T EmmerDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Rami KhoriatyDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Jiandie D LinDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-8069-5647
David GinsburgLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-6436-8942
University of Michigan · USLoyola University Chicago · USPeking University · CN

Funding

The molecular pathophysiology of the congenital dyserythropoietic anemiasR01HL148333 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Rami Khoriaty · 2019 to 2026
$4.6M
The Molecular Genetics of HemostasisR35HL135793 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GINSBURG, DAVID · 2017 to 2023
$4.1M
The Molecular Genetics of HemostasisR35HL171421 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Ginsburg · 2024 to 2026
$2.8M
The regulation of thrombopoietin levelsR01HL157062 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHORIATY, RAMI · 2021 to 2024
$2.1M
Molecular Regulation of LDL Receptor ExpressionR01HL167733 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brian T Emmer · 2024 to 2026
$1.9M
Cholesterol regulation by the cargo receptor SURF4K08HL148552 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EMMER, BRIAN T · 2019 to 2023
$788k
Examining Molecular Regulation of Unconventional Cytoplasmic Protein SecretionR00GM141268 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI ABBINENI, PRABHODH SAI · 2023 to 2025
$747k
Examining Molecular Regulation of Unconventional Cytoplasmic Protein SecretionK99GM141268 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABBINENI, PRABHODH SAI · 2021 to 2022
$200k
NHLBI NIH HHS K08 HL148552NHLBI NIH HHS R01 HL148333NHLBI NIH HHS R01 HL157062NHLBI NIH HHS R01 HL167733NHLBI NIH HHS R35 HL135793NHLBI NIH HHS R35 HL171421NIGMS NIH HHS K99 GM141268NIGMS NIH HHS R00 GM141268
6 · The paper itself

Abstract

Proteins carrying a signal peptide and/or a transmembrane domain enter the intracellular secretory pathway at the endoplasmic reticulum (ER) and are transported to the Golgi apparatus via COPII vesicles or tubules. SAR1 initiates COPII coat assembly by recruiting other coat proteins to the ER membrane. Mammalian genomes encode two

Indexed as

Monomeric GTP-Binding ProteinsAnimalsCOP-Coated VesiclesEndoplasmic ReticulumGTP-Binding ProteinsHepatocytesHumansMiceMice, KnockoutGTP-Binding ProteinsMonomeric GTP-Binding ProteinsSAR1A protein, humanSAR1B protein, humanSar1b protein, mouseSARA protein, mouseCOPIIendoplasmic reticulumSAR1

Identifiers

PMID38687799
PMCPMC11087783
OpenAlexW4396530271

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.