Evidence map›Paper›PMID 38687676›Full record

ArticleeLife2024

A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation.

Xiao-Ru Chen, Karuna Dixit, Yuan Yang, Mark I McDermott, Hasan Tanvir Imam, Vytas A Bankaitis, Tatyana I Igumenova

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Fuzziness in enzymatic catalysis.Current opinion in structural biology · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiao-Ru Chen *Department of Biochemistry & Biophysics, Texas A&M University, College Station, United States.ORCID https://orcid.org/0000-0002-2051-889X
Karuna Dixit *Department of Biochemistry & Biophysics, Texas A&M University, College Station, United States.ORCID https://orcid.org/0000-0003-3583-2512
Yuan YangDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, United States.ORCID https://orcid.org/0000-0002-9538-6369
Mark I McDermottDepartment of Cell Biology & Genetics, Texas A&M University, College Station, United States.
Hasan Tanvir ImamDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, United States.
Vytas A BankaitisDepartment of Cell Biology & Genetics, Texas A&M University, College Station, United States.ORCID https://orcid.org/0000-0002-1654-6759
Tatyana I IgumenovaDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, United States.ORCID https://orcid.org/0000-0003-3772-7484
Texas A&M University · US

Funding

The Biology and Biochemistry of Lipid Transfer Protein-Regulated Phosphoinositide SignalingR35GM131804 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Vytas A Bankaitis · 2019 to 2026
$4.5M
Structural and Functional Studies of Protein Kinase C RegulationR01GM108998 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI Tatyana I. Igumenova · 2014 to 2026
$3.3M
NIGMS NIH HHS R01 GM108998NIGMS NIH HHS R35 GM131804NIGMS NIH HHS R35GM131804NIGMS NIH HHS RO1GM108998
6 · The paper itself

Abstract

Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P

Indexed as

NIMA-Interacting Peptidylprolyl IsomeraseProtein BindingHumansProtein ConformationProtein Kinase CNIMA-Interacting Peptidylprolyl IsomerasePIN1 protein, humanProtein Kinase Cbivalent bindinghumanmolecular biophysicsnon-catalytic mechanismPin1 peptidyl-prolyl isomeraseprotein kinase Cprotein kinase C degradationsignalingstructural biology

Identifiers

PMID38687676
PMCPMC11060717
OpenAlexW4396508423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.