Evidence map›Paper›PMID 38687421›Full record

ArticleBiological trace element research2025

Trace Element Concentration in the Blood and Aqueous Humor of Subjects with Eye Cataract.

Giovanni Forte, Edoardo Trovato Battagliola, Mariaelena Malvasi, Niccolò Ruberti, Pierluigi Daniele, Alberto Mantovani, Beatrice Bocca, Elena Pacella

Abstract read
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In one paragraph

Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. From environmental exposure to retinal pathology: epidemiological and mechanistic insights into multi-metal driven ocular diseases.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giovanni ForteDepartment of Environment and Health, Italian National Institute of Health, 00161, Rome, Italy.
Edoardo Trovato BattagliolaDepartment of Sense Organs, University of Rome La Sapienza, 00161, Rome, Italy.
Mariaelena MalvasiDepartment of Sense Organs, University of Rome La Sapienza, 00161, Rome, Italy.
Niccolò RubertiDepartment of Sense Organs, University of Rome La Sapienza, 00161, Rome, Italy.
Pierluigi DanieleDepartment of Sense Organs, University of Rome La Sapienza, 00161, Rome, Italy.
Alberto MantovaniStudy Center KOS, 00144, Rome, Italy.
Beatrice BoccaDepartment of Environment and Health, Italian National Institute of Health, 00161, Rome, Italy.
Elena PacellaDepartment of Sense Organs, University of Rome La Sapienza, 00161, Rome, Italy. elena.pacella@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cataract, characterized by the opacification of the lens, is the leading cause of reversible blindness and visual impairment globally. The study aims to investigate the role of trace elements such as Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se, and Zn in the development and severity of cataract. Elements were quantified by inductively coupled plasma mass spectrometry in blood and aqueous humor of 32 cataract cases and 27 controls living in the Latium region, Italy. The association between element concentration in blood and aqueous humor and cataract severity, gender, and age of subjects were also assessed. Results showed Cr levels significantly elevated in both blood and aqueous humor of cataract cases, with concentrations that increased with cataract severity. In addition, blood Pb levels were significantly higher in older cases and positively correlated with the age of cataract cases, while blood Co and Cu levels negatively correlated with cataract severity, suggesting changes in the levels of these elements. In conclusion, this study provides evidence of the involvement of specific elements in cataract development and severity, and the findings highlighted important avenues for future research. Understanding the biological mechanism underlying element-induced cataract may contribute to preventing cataractogenesis and providing targeted interventions.

Indexed as

Aqueous HumorCataractTrace ElementsAgedAged, 80 and overFemaleHumansMaleMiddle AgedTrace ElementsCataractEssential elementsPreventionRisk factorsToxic elements

Identifiers

PMID38687421

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.