Evidence map›Paper›PMID 38687372›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

[

Miriam Pepponi, Valentina Berti, Elsa Fasciglione, Flavio Montanini, Letizia Canu, Fabrice Hubele, Elisabetta Abenavoli, Vittorio Briganti, Elena Rapizzi, Anne Charpiot and 4 more

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Miriam Pepponi *Nuclear Medicine and Molecular Imaging, ICANS, University Hospitals of Strasbourg, University of Strasbourg, Strasbourg, France.
Valentina Berti *Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Elsa FasciglioneEndocrinology, Diabetology, Nutrition, University Hospitals of Strasbourg, Strasbourg University, Strasbourg, France.
Flavio MontaniniNuclear Medicine Unit, Careggi University Hospital, Florence, Italy.
Letizia CanuDepartment of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Fabrice HubeleNuclear Medicine and Molecular Imaging, ICANS, University Hospitals of Strasbourg, University of Strasbourg, Strasbourg, France.
Elisabetta AbenavoliNuclear Medicine Unit, Careggi University Hospital, Florence, Italy.
Vittorio BrigantiNuclear Medicine Unit, Careggi University Hospital, Florence, Italy.
Elena RapizziDepartment of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Anne CharpiotOtolaryngology and Maxillofacial Surgery, University Hospitals of Strasbourg, Strasbourg, France.
David TaiebLa Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.
Karel PacakEunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD, USA.
Bernard GoichotEndocrinology, Diabetology, Nutrition, University Hospitals of Strasbourg, Strasbourg University, Strasbourg, France.
Alessio ImperialeNuclear Medicine and Molecular Imaging, ICANS, University Hospitals of Strasbourg, University of Strasbourg, Strasbourg, France. a.imperiale@icans.eu.ORCID 0000-0003-2751-5146

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the [

methodsSporadic and SDHx HNPGL patients, who underwent [

results34 patients harboring 60 HNPGLs (51 SDHx in 25 patients) were included. Three sporadic and nine SDHx HNPGLs were metastatic. At stepwise discriminant analysis, both GLSZM-Zone Size Non-Uniformity (ZSNU, reflecting tumor heterogeneity) and IB-TLSRE (total lesion somatostatin receptor expression) were independent predictors of genetic status, with 96.4% of lesions and 91.6% of patients correctly classified after cross validation (p < 0.001). Among non-metastatic patients, GLSZM-ZSNU and IB-TLSRE were significantly higher in sporadic than SDHx HNPGLs (p < 0.001). No differences were revealed in metastatic patients. Decision-tree analysis highlights multifocality and IB-TLSRE as useful variables, correctly identifying 6/9 sporadic and 24/25 SDHx patients. Model failed to classify one SDHA and three sporadic patients (2 metastatic).

conclusionRadiomics features GLSZM-ZSNU and IB-TLSRE appear to reflect HNPGLs SDHx status and tumor behavior (metastatic vs. non-metastatic). If validated, especially IB-TLSRE might represent a simple and time-efficient radiomic index for SDHx variants early screening and prediction of tumor behavior in HNPGL cases.

Indexed as

Head and Neck NeoplasmsOctreotideOrganometallic CompoundsParagangliomaPositron Emission Tomography Computed TomographyAdultAgedFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedPilot ProjectsRadiomicsRetrospective StudiesSuccinate DehydrogenaseGa(III)-DOTATOCOctreotideOrganometallic CompoundsSuccinate Dehydrogenase[68Ga]DOTATOCHead and neckNeuroendocrineParagangliomaPETRadiomicsSuccinate dehydrogenase

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.