Evidence map›Paper›PMID 38687347›Full record

ArticleAnnals of hematology2024

Impact of the presence and number of chromosomal abnormalities on the clinical outcome in Waldenström Macroglobulinemia: a monocentric experience.

Nicolò Danesin, Laura Bonaldi, Annalisa Martines, Silvia Nalio, Roberta Bertorelle, Sofia Compagno, Raffaella Marcato, Sabrina Manni, Federico Scarmozzino, Marco Pizzi and 6 more

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Article in Annals of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nicolò DanesinHematology Unit, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Laura BonaldiImmunology and Molecular Oncology Diagnostics, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
Annalisa MartinesImmunology and Molecular Oncology Diagnostics, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
Silvia NalioImmunology and Molecular Oncology Diagnostics, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
Roberta BertorelleImmunology and Molecular Oncology Diagnostics, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
Sofia CompagnoImmunology and Molecular Oncology Diagnostics, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
Raffaella MarcatoImmunology and Molecular Oncology Diagnostics, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
Sabrina ManniHematology Unit, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Federico ScarmozzinoSurgical Pathology and Cytopathology Unit, Department of Medicine, University of Padova, Padua, Italy.
Marco PizziSurgical Pathology and Cytopathology Unit, Department of Medicine, University of Padova, Padua, Italy.
Angelo Paolo Dei TosSurgical Pathology and Cytopathology Unit, Department of Medicine, University of Padova, Padua, Italy.
Alessandro CelliniHematology Unit, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Greta ScapinelloHematology Unit, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Andrea VisentinHematology Unit, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Livio TrentinHematology Unit, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Francesco PiazzaHematology Unit, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy. francesco.piazza@unipd.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognostic and predictive role of specific gene mutations in Waldenström Macroglobulinemia (WM) is well-ascertained whereas the clinical impact of chromosome aberrations is far less known. Recent work has provided initial evidence for an adverse prognostic impact of some aberrations, such as del(6q), while other studies suggest a possible relationship between some clinical features (e.g. advanced age and/or inflammatory status) and specific cytogenetic abnormalities. To add to the still limited knowledge on WM cytogenetics and its clinical implications, we herein report our experience in a cohort of WM patients across 23 years. Based on our retrospective study, we found that abnormal karyotype was more represented in older patients and maintained a statistically significant independence from other molecular, clinical, and biological features related to WM. The presence and number of cytogenetic aberrations correlated with inferior overall and progression-free survival outcomes regardless of the type of single chromosome aberration. Our data suggests that the role of the altered karyotype deserves to be further clarified especially in elderly WM patients, in whom cytogenetic abnormalities and disease biology appear to be characterized by a higher degree of complexity.

Indexed as

Chromosome AberrationsWaldenstrom MacroglobulinemiaAbnormal KaryotypeAdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesChromosomal abnormalitiesCytogeneticsNon-Hodgkin LymphomaWaldenström Macroglobulinemia

Identifiers

PMID38687347
PMCPMC11283403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.