Evidence map›Paper›PMID 38687339›Full record

Trial reportAdvances in wound care2025

Improved Wound Healing by Direct Cold Atmospheric Plasma Once or Twice a Week: A Randomized Controlled Trial on Chronic Venous Leg Ulcers.

Olaf Bakker, Paulien Smits, Chantal van Weersch, Melissa Quaaden, Esther Bruls, Angela van Loon, Joost van der Kleij

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Advances in wound care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04922463 (PLASOMA Efficacy & Technology Health), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04922463 naterminatednot on this map

PLASOMA Efficacy & Technology Health (PETH) Study: A Post-market Randomised Controlled Efficacy Study of PLASOMA on Wound Healing in Chronic Venous Leg Ulcers

TypeinterventionalSponsorPlasmacureRan2021 to 2023Enrolled46ConditionsVenous Leg UlcerArmsPLASOMA
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Cold Atmospheric Plasma in Wound Healing: Molecular Mechanism of Action.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Penetration depth of cold atmospheric plasma into biological tissue: a review.Frontiers in bioengineering and biotechnology · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Olaf BakkerSt. Antonius hospital, Nieuwegein, The Netherlands.
Paulien SmitsPlasmacure B.V., Eindhoven, The Netherlands.ORCID 0000-0002-0371-3933
Chantal van WeerschZuyderland Thuiszorg, Sittard, The Netherlands.
Melissa QuaadenZuyderland Thuiszorg, Sittard, The Netherlands.
Esther BrulsZuyderland Thuiszorg, Sittard, The Netherlands.
Angela van LoonThebe Zorg Thuis, Tilburg, The Netherlands.
Joost van der KleijIndependent principal investigator, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Plasma GasesVaricose UlcerWound HealingAgedAged, 80 and overChronic DiseaseFemaleHumansMaleMiddle AgedNetherlandsTreatment OutcomePlasma Gasesadvanced therapycold plasma treatmentcomplex woundsvenous leg ulcerwound healing

Identifiers

PMID38687339
PMCPMC11839521

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.