ArticleRadiology2024
Addition of Contrast-enhanced Mammography to Tomosynthesis for Breast Cancer Detection in Women with a Personal History of Breast Cancer: Prospective TOCEM Trial Interim Analysis.
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Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Interval Cancers after Negative Screening Contrast-enhanced Mammography.Radiology. Imaging cancer · 2026Article
- ESR Essentials: post-treatment breast cancer surveillance from mammography to a more personalised approach-practice recommendations by the European Society of Breast Imaging.European radiology · 2026Review
- Emerging Approaches in Breast Cancer: From Molecular Mechanisms to Diagnosis and Therapeutic Strategies.Oncology research · 2026Review
- Contrast-Enhanced Mammography in Breast Cancer Follow-Up: Diagnostic Value in Suspected Recurrence.Journal of imaging · 2025Article
- 조영증강 유방촬영술: 현재의 임상적 활용과 미래 방향에 대한 종합적 고찰.Journal of the Korean Society of Radiology · 2025Review
- Molecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial.Radiology · 2025Article
- Inter-reader agreement of the BI-RADS CEM lexicon.European radiology · 2025Article
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Authors and funding
20 authors.
Wendie A BergFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0000-0002-8792-6185
Jeremy M BergFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).
Andriy I BandosFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0000-0001-5629-1415
Adrienne VargoFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0009-0009-3632-1512
Denise M ChoughFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0009-0002-2841-4048
Amy H LuFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0009-0003-4598-0743
Marie A GanottFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).
Amy E KellyFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0000-0002-9971-8033
Bronwyn E NairFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).
Jamie Y HartmanFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0009-0004-5828-121X
Uzma WaheedFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0000-0001-8208-9456
Christiane M HakimFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0009-0008-6206-9907
Kimberly S HarnistFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).
Ruthane F ReginellaFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0009-0006-6798-5969
Dilip D ShindeFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0009-0009-6200-2945
Bea A CarlinFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).
Cathy S CohenFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).
Luisa P WallaceFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).
Jules H SumkinFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).
Margarita L ZuleyFrom the Departments of Radiology (W.A.B., A.V., D.M.C., A.H.L., M.A.G., A.E.K., B.E.N., J.Y.H., U.W., C.M.H., K.S.H., R.F.R., D.D.S., B.A.C., C.S.C., L.P.W., J.H.S., M.L.Z.) and Computational and Systems Biology (J.M.B.), University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA 15213; Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, Pa (W.A.B., A.V., D.M.C., A.H.L., M.A.G., C.M.H., D.D.S., C.S.C., J.H.S., M.L.Z.); and Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pa (A.I.B.).ORCID 0000-0003-2127-8346
Funding
Sequential Reading Effects in Digital Breast TomosynthesisR01CA237827 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ABBEY, CRAIG KENDALL, BANDOS, ANDRIY · 2020 to 2023
$1.6MNCI NIH HHS R01 CA237827
Abstract
Background Digital breast tomosynthesis (DBT) is often inadequate for screening women with a personal history of breast cancer (PHBC). The ongoing prospective Tomosynthesis or Contrast-Enhanced Mammography, or TOCEM, trial includes three annual screenings with both DBT and contrast-enhanced mammography (CEM). Purpose To perform interim assessment of cancer yield, stage, and recall rate when CEM is added to DBT in women with PHBC. Materials and Methods From October 2019 to December 2022, two radiologists interpreted both examinations: Observer 1 reviewed DBT first and then CEM, and observer 2 reviewed CEM first and then DBT. Effects of adding CEM to DBT on incremental cancer detection rate (ICDR), cancer type and node status, recall rate, and other performance characteristics of the primary radiologist decisions were assessed. Results Among the participants (mean age at entry, 63.6 years ± 9.6 [SD]), 1273, 819, and 227 women with PHBC completed year 1, 2, and 3 screening, respectively. For observer 1, year 1 cancer yield was 20 of 1273 (15.7 per 1000 screenings) for DBT and 29 of 1273 (22.8 per 1000 screenings; ICDR, 7.1 per 1000 screenings [95% CI: 3.2, 13.4]) for DBT plus CEM (
Indexed as
Breast NeoplasmsContrast MediaMammographyAgedBreastEarly Detection of CancerFemaleHumansMiddle AgedProspective StudiesRadiographic Image EnhancementContrast Media
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