Evidence map›Paper›PMID 38687015›Full record

ArticleAntimicrobial agents and chemotherapy2024

Efficacy of an oral lipid nanocrystal formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis.

Yiyou Gu, Teclegiorgis Gebremariam, Sondus Alkhazraji, Eman Youssef, Sabrina El-Gamal, Theresa Matkovits, Jenel Cobb, Raphael Mannino, Ashraf S Ibrahim

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yiyou GuThe Lundquist Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Teclegiorgis GebremariamThe Lundquist Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Sondus AlkhazrajiThe Lundquist Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Eman YoussefThe Lundquist Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Sabrina El-GamalThe Lundquist Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Theresa MatkovitsMatinas Biopharma, BedminsterBioPharma, Bedminster, New Jersey, USA.ORCID 0009-0003-3761-9149
Jenel CobbMatinas Biopharma, BedminsterBioPharma, Bedminster, New Jersey, USA.ORCID 0009-0008-6516-7684
Raphael ManninoMatinas Biopharma, BedminsterBioPharma, Bedminster, New Jersey, USA.
Ashraf S IbrahimThe Lundquist Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA.ORCID 0000-0003-3787-8530

Funding

Novel Toxins and Receptors in Mucormycosis Pathogenesis and TreatmentR01AI063503 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI IBRAHIM, ASHRAF S. · 2006 to 2025
$7.3M
Iron Uptake and Mucormycosis PathogenesisR56AI063503 · NIAID · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI IBRAHIM, ASHRAF S. · 2005 to 2005
$281k
HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) AI063503Matinas BioPharma 22802NIAID NIH HHS R01 AI063503NIAID NIH HHS R56 AI063503
6 · The paper itself

Abstract

Invasive mucormycosis (IM) is associated with high mortality and morbidity. MAT2203 is an orally administered lipid nanocrystal formulation of amphotericin B, which has been shown to be safe and effective against other fungal infections. We sought to compare the efficacy of MAT2203 to liposomal amphotericin B (LAMB) treatment in a neutropenic mouse model of IM due to

Indexed as

Amphotericin BAntifungal AgentsMucormycosisNanoparticlesNeutropeniaAdministration, OralAnimalsDisease Models, AnimalFemaleLung Diseases, FungalMiceMucorRhizopusAmphotericin BAntifungal Agentsliposomal amphotericin Bamphotericin Bantifungal agentslipid nanocrystalliposomal amphotericin BMAT2203Mucormucormycosismurineoral amphotericin BRhizopus

Identifiers

PMID38687015
PMCPMC11620485

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.