Evidence map›Paper›PMID 38687006›Full record

ArticleMicrobiology (Reading, England)2024

Exploiting cooperative pathogen behaviour for enhanced antibiotic potency: A Trojan horse approach.

Alper Mutlu, Emily J Vanderpool, Kendra P Rumbaugh, Stephen P Diggle, Ashleigh S Griffin

Abstract read
In one paragraph

Article in Microbiology (Reading, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Alper MutluDepartment of Biology, University of Oxford, Oxford, UK.
Emily J VanderpoolTexas Tech University Health Sciences Center, Lubbock, USA.
Kendra P RumbaughTexas Tech University Health Sciences Center, Lubbock, USA.
Stephen P DiggleCenter for Microbial Dynamics and Infection, School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA.
Ashleigh S GriffinDepartment of Biology, University of Oxford, Oxford, UK.

Funding

Understanding in vivo antibiotic resistance in diverse Pseudomonas aeruginosa populationsR01AI153116 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI DIGGLE, STEPHEN PAUL · 2021 to 2025
$2.3M
NIAID NIH HHS R01 AI153116
6 · The paper itself

Abstract

Antimicrobial resistance poses an escalating global threat, rendering traditional drug development approaches increasingly ineffective. Thus, novel alternatives to antibiotic-based therapies are needed. Exploiting pathogen cooperation as a strategy for combating resistant infections has been proposed but lacks experimental validation. Empirical findings demonstrate the successful invasion of cooperating populations by non-cooperating cheats, effectively reducing virulence

Indexed as

Anti-Bacterial AgentsPseudomonas aeruginosaPseudomonas InfectionsQuorum SensingAnimalsBacterial ProteinsDrug Resistance, BacterialHumansMiceMicrobial Sensitivity TestsVirulenceAnti-Bacterial AgentsBacterial Proteinsantimicrobial resistancecheatcooperationmicrobial social evolutionquorum sensingtrojan cheatvirulence

Identifiers

PMID38687006
PMCPMC11084615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.