ArticleJournal of proteome research2024
Endogenous Protein-Protein Interaction Network of the NPC Cholesterol Transporter 1 in the Cerebral Cortex.
Roshan Javanshad, Thu T A Nguyen, Ruth D Azaria, Wenping Li, Daisy Edmison, Liang-Wei Gong, Swetha Gowrishankar, Andrew P Lieberman, Mark L Schultz, Stephanie M Cologna
Abstract read
In one paragraphArticle in Journal of proteome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Roshan JavanshadDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Thu T A NguyenDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Ruth D AzariaDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-1686-2591 Wenping LiDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0001-5917-5380 Daisy EdmisonDepartment of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Liang-Wei GongDepartment of Biological Sciences, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Swetha GowrishankarDepartment of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Andrew P LiebermanDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.
Mark L SchultzStead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, United States.ORCID 0000-0002-3149-4424 Stephanie M ColognaDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0002-3541-3361 Funding
Therapeutic Targets for Niemann-Pick Type C NeurodegenerationR01NS122746 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P · 2021 to 2025
$3.0MNovel Therapeutic Approaches for NPC DiseaseR01NS124784 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Vinay Aakalu, Stephanie M Cologna · 2022 to 2026
$2.9MElucidating the role of Adaptor Protein complex-4 in regulating axonal autophagic and lysosomal pathwaysR01AG074248 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Swetha Gowrishankar · 2022 to 2026
$2.4MDevelopment of autophagy modulators for evaluation as a therapeutic strategy for Niemann-Pick Type CR01NS114413 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COLOGNA, STEPHANIE M · 2020 to 2024
$2.0MModulation of autophagic flux as a therapeutic strategy for Alzheimer's diseaseRF1AG076653 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GOWRISHANKAR, SWETHA · 2022 to 2022
$1.8MNiemann-Pick C liver-specific proteostasis and pathologyK01DK124450 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHULTZ, MARK LOUIS · 2021 to 2024
$493kNIA NIH HHS R01 AG074248NIA NIH HHS RF1 AG076653NIDDK NIH HHS K01 DK124450NINDS NIH HHS R01 NS114413NINDS NIH HHS R01 NS122746NINDS NIH HHS R01 NS124784
6 · The paper itselfAbstract
NPC intracellular cholesterol transporter 1 (NPC1) is a multipass, transmembrane glycoprotein mostly recognized for its key role in facilitating cholesterol efflux. Mutations in the
Indexed as
Cerebral CortexNiemann-Pick C1 ProteinProtein Interaction MapsAnimalsCholesterolHumansIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutMutationNeuronsNiemann-Pick Disease, Type CProteomicsCholesterolIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinNPC1 protein, humanNpc1 protein, mouseInteractomeLysosomal Storage DisorderNeurodegenerative DiseaseNiemann-Pick type CTransmembrane Protein
Identifiers
PMID38686625
PMCPMC12131329
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390