Evidence map›Paper›PMID 38686623›Full record

SynthesisCancer medicine2024

Cancer risks related to intellectual disabilities: A systematic review.

Amina Banda, Jenneken Naaldenberg, Aura Timen, Agnies van Eeghen, Geraline Leusink, Maarten Cuypers

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amina BandaDepartment of Primary and Community Care, Radboud university medical centre, Nijmegen, the Netherlands.ORCID 0000-0001-8297-3137
Jenneken NaaldenbergDepartment of Primary and Community Care, Radboud university medical centre, Nijmegen, the Netherlands.
Aura TimenDepartment of Primary and Community Care, Radboud university medical centre, Nijmegen, the Netherlands.
Agnies van EeghenEmma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Geraline LeusinkDepartment of Primary and Community Care, Radboud university medical centre, Nijmegen, the Netherlands.
Maarten CuypersDepartment of Primary and Community Care, Radboud university medical centre, Nijmegen, the Netherlands.ORCID 0000-0003-1715-4375
Radboud University Nijmegen · NLEmma Kinderziekenhuis · NL

Funding

ZonMw 641001100
6 · The paper itself

Abstract

backgroundPeople with intellectual disabilities (ID) face barriers in cancer care contributing to poorer oncological outcomes. Yet, understanding cancer risks in the ID population remains incomplete.

aimTo provide an overview of cancer incidence and cancer risk assessments in the entire ID population as well as within ID-related disorders.

methodsThis systematic review examined cancer risk in the entire ID population and ID-related disorders. We systematically searched PubMed (MEDLINE) and EMBASE for literature from January 1, 2000 to July 15, 2022 using a search strategy combining terms related to cancer, incidence, and ID.

resultsWe found 55 articles assessing cancer risks in the ID population at large groups or in subgroups with ID-related syndromes, indicating that overall cancer risk in the ID population is lower or comparable with that of the general population, while specific disorders (e.g., Down's syndrome) and certain genetic mutations may elevate the risk for particular cancers. DISCUSSION: The heterogeneity within the ID population challenges precise cancer risk assessment at the population level. Nonetheless, within certain subgroups, such as individuals with specific ID-related disorders or certain genetic mutations, a more distinct pattern of varying cancer risks compared to the general population becomes apparent.

conclusionMore awareness, and personalized approach in cancer screening within the ID population is necessary.

Indexed as

Intellectual DisabilityNeoplasmsEarly Detection of CancerHumansIncidenceRisk AssessmentRisk Factors

Identifiers

PMID38686623
PMCPMC11058689
OpenAlexW4396519228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.