Evidence map›Paper›PMID 38686621›Full record

Trial reportThe journals of gerontology. Series B, Psychological sciences and social sciences2024

The Effects of Computerized Cognitive Training in Older Adults' Cognitive Performance and Biomarkers of Structural Brain Aging.

Hyun Kyu Lee, Chandramallika Basak, Sarah-Jane Grant, Nicholas R Ray, Paulina A Skolasinska, Chris Oehler, Shuo Qin, Andrew Sun, Evan T Smith, G Hulon Sherard and 3 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series B, Psychological sciences and social sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03197454 (Brain Enhancement Training Towards Elders Resilience to Aging), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03197454 nacompletednot on this map

Brain Enhancement Training Towards Elders Resilience to Aging (BETTER Aging)

TypeinterventionalSponsorPosit Science CorporationRan2018 to 2021Enrolled147ConditionsAge-related Cognitive DeclineArmsComputerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hyun Kyu LeeDepartment of Research and Development, Posit Science Corporation, San Francisco, California, USA.
Chandramallika BasakDepartment of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
Sarah-Jane GrantDepartment of Research and Development, Posit Science Corporation, San Francisco, California, USA.
Nicholas R RayDepartment of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
Paulina A SkolasinskaDepartment of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
Chris OehlerDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.
Shuo QinDepartment of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
Andrew SunDepartment of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
Evan T SmithDepartment of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
G Hulon SherardDepartment of Psychology, University of Texas at Dallas, Dallas, Texas, USA.
Adriana Rivera-DompencielDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.
Mike MerzenichDepartment of Research and Development, Posit Science Corporation, San Francisco, California, USA.
Michelle W VossDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.

Funding

Plasticity-based Adaptive Cognitive Remediation for Alzheimers Disease Phase IIR44AG047722 · NIA · POSIT SCIENCE CORPORATION · PI LEE, HYUN KYU · 2017 to 2025
$4.6M
Plasticity-based Adaptive Cognitive Remediation for Alzheimer DiseaseR43AG047722 · NIA · POSIT SCIENCE CORPORATION · PI LEE, HYUN KYU · 2014 to 2015
$698k
NIA NIH HHS AG047722NIA NIH HHS R43 AG047722NIA NIH HHS R44 AG047722
6 · The paper itself

Abstract

objectivesCognitive training (CT) has been investigated as a means of delaying age-related cognitive decline in older adults. However, its impact on biomarkers of age-related structural brain atrophy has rarely been investigated, leading to a gap in our understanding of the linkage between improvements in cognition and brain plasticity. This study aimed to explore the impact of CT on cognitive performance and brain structure in older adults.

methodsOne hundred twenty-four cognitively normal older adults recruited from 2 study sites were randomly assigned to either an adaptive CT (n = 60) or a casual game training (active control, AC, n = 64).

resultsAfter 10 weeks of training, CT participants showed greater improvements in the overall cognitive composite score (Cohen's d = 0.66, p < .01) with nonsignificant benefits after 6 months from the completion of training (Cohen's d = 0.36, p = .094). The CT group showed significant maintenance of the caudate volume as well as significant maintained fractional anisotropy in the left internal capsule and in left superior longitudinal fasciculus compared to the AC group. The AC group displayed an age-related decrease in these metrics of brain structure. DISCUSSION: Results from this multisite clinical trial demonstrate that the CT intervention improves cognitive performance and helps maintain caudate volume and integrity of white matter regions that are associated with cognitive control, adding to our understanding of the changes in brain structure contributing to changes in cognitive performance from adaptive CT. CLINICAL

trial registrationNCT03197454.

Indexed as

BrainAgedAgingAtrophyBiomarkersCognitionCognitive AgingCognitive Behavioral TherapyCognitive DysfunctionCognitive TrainingFemaleHumansMagnetic Resonance ImagingMaleNeuronal PlasticityBiomarkersAge-related cognitive declineBrain plasticityComputerized cognitive trainingGray matter volumeWhite matter integrity

Identifiers

PMID38686621
PMCPMC11165429

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.