Evidence map›Paper›PMID 38686575›Full record

SynthesisLa Medicina del lavoro2024

Exposure Assessment and Monitoring of Antiblastic Drugs Preparation in Health Care Settings: A Systematic Review.

Francesca Borghi, Carolina Zellino, Arianna Zago, Giovanni De Vito, Rocco Loris Del Vecchio, Andrea Cattaneo, Andrea Spinazzè, Domenico Maria Cavallo

Abstract readSystematic Review
In one paragraph

Synthesis in La Medicina del lavoro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesca BorghiDepartment of Medical and Surgical Sciences, University of Bologna, Via Pelagio Palagi 9, 40138 Bologna (Ita-ly).
Carolina ZellinoDepartment of Science and High Technology, University of Insubria, via Valleggio 11, 22100 Como (Italy).
Arianna ZagoDepartment of Science and High Technology, University of Insubria, via Valleggio 11, 22100 Como (Italy).
Giovanni De VitoDepartment of Medicine and Surgery, University of Insubria, Via Guicciardini 9, 21100 Varese (Italy).
Rocco Loris Del VecchioDepartment of Medicine and Surgery, University of Insubria, Via Guicciardini 9, 21100 Varese (Italy).
Andrea CattaneoDepartment of Science and High Technology, University of Insubria, via Valleggio 11, 22100 Como (Italy).
Andrea SpinazzèDipartimento di Scienza e Alta Tecnologia Università degli Studi dell'Insubria Via Valleggio, 11 - 22100 Como.
Domenico Maria CavalloDepartment of Science and High Technology, University of Insubria, via Valleggio 11, 22100 Como (Italy).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several antiblastic drugs (ADs) are classified as carcinogenic, mutagenic, and/or toxic for reproduction. Despite established guidelines and safe handling technologies, ADs contamination of the work environments could occur in healthcare settings, leading to potential exposure of healthcare staff. This systematic review aims to investigate the main techniques and practices for assessing ADs occupational exposure in healthcare settings. The reviewed studies unveil that workplace contamination by ADs appears to be a still-topical problem in healthcare settings. These issues are linked to difficulties in guaranteeing: (i) the adherence to standardized protocols when dealing with ADs, (ii) the effective use of personal protective equipment by operators involved in the administration or management of ADs, (iii) a comprehensive training of the healthcare personnel, and (iv) a thorough health surveillance of exposed workers. A "multi-parametric" approach emerges as a desirable strategy for exposure assessment. In parallel, exposure assessment should coincide with the introduction of novel technologies aimed at minimizing exposure (i.e., risk management). Assessment must consider various departments and health operators susceptible to ADs contamination, with a focus extended beyond worst-case scenarios, also considering activities like surface cleaning and logistical tasks related to ADs management. A comprehensive approach in ADs risk assessment enables the evaluation of distinct substance behaviors and subsequent exposure routes, affording a more holistic understanding of potential risks.

Indexed as

Occupational ExposureDrug CompoundingHealth FacilitiesHealth PersonnelHumansPersonal Protective EquipmentRisk Assessment

Identifiers

PMID38686575
PMCPMC11181217

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.