Evidence map›Paper›PMID 38686500›Full record

ArticleDrug testing and analysis2025

Is there a relationship between abuse of alcohol and illicit drugs seen in hair results?

Fritz Pragst, André Niebel, Denise Thurmann, Monique Dullin, Susann Eichberg, Frederike Mörlein, Sven Hartwig

Abstract read
In one paragraph

Article in Drug testing and analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fritz PragstInstitute of Legal Medicine, University Medicine Charité, Berlin, Germany.ORCID https://orcid.org/0000-0002-5639-7049
André NiebelInstitute of Legal Medicine, University Medicine Charité, Berlin, Germany.
Denise ThurmannInstitute of Legal Medicine, University Medicine Charité, Berlin, Germany.
Monique DullinInstitute of Legal Medicine, University Medicine Charité, Berlin, Germany.
Susann EichbergInstitute of Legal Medicine, University Medicine Charité, Berlin, Germany.
Frederike MörleinInstitute of Legal Medicine, University Medicine Charité, Berlin, Germany.
Sven HartwigInstitute of Legal Medicine, University Medicine Charité, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combined use of alcohol and illicit drugs is a serious health and social problem. In this study, it was examined, whether a relationship between alcohol and drug abuse can be ascertained by comparison of alcohol marker and drug concentrations in hair. In the frame of a social support system for families with parental abuse of illicit drugs, hair samples were analyzed between 2011 and 2022 for methadone, heroin (6-acetylmorphine), cocaine, amphetamine, ecstasy (MDMA), cannabinoids (THC), and the alcohol markers ethyl glucuronide (EtG) and ethyl palmitate (EtPa). For 1314 hair samples from adolescent and adult family members, the hair results show a prevalence of combined occasional or regular drug use and social or abusive alcohol use of 41%-60% except heroin (35%). The drug concentrations were statistically compared in the three categories of abstinence or moderate drinking, social drinking, and alcohol abuse. For the most frequently detected drug cocaine (n = 703), a significant increase of the concentrations with rising alcohol consumption was found. The frequent detection of cocaethylene proved the preferred simultaneous intake of both substances. For THC (n = 489), no significant difference between the alcohol consumer groups was seen. Concerning the less frequently detected methadone (n = 89), 6-acetylmorphine (n = 92), amphetamine (n = 123), and MDMA (n = 105), no clear trend between drug and alcohol marker results was determined. It is concluded that the evaluation of hair results is an appropriate way to study the extent of combined drug-alcohol consumption and complements other studies based on acquisition of consumption data by interview or questionnaire.

Indexed as

AlcoholismHairIllicit DrugsSubstance Abuse DetectionSubstance-Related DisordersAdolescentAdultAlcohol DrinkingFemaleHumansMaleMiddle AgedYoung AdultIllicit Drugsdrug–alcohol co‐abuseEtG in hairillicit drugs in hairparental substance abuse

Identifiers

PMID38686500
PMCPMC11842179

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.