Evidence map›Paper›PMID 38686416›Full record

ArticleSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi2024

[A study on the regulation of motor behavior in mouse based on temporal interference].

Haoran Zhu, Ruituo Huai, Pingqiu Zhang, Hui Wang, Junqing Yang, Tao Yin, Zhihao Yu, Feng Shao

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Haoran ZhuCollege of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao, Shangdong 266510, P. R. China.
Ruituo HuaiCollege of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao, Shangdong 266510, P. R. China.
Pingqiu ZhangCollege of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao, Shangdong 266510, P. R. China.
Hui WangCollege of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao, Shangdong 266510, P. R. China.
Junqing YangCollege of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao, Shangdong 266510, P. R. China.
Tao YinCollege of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao, Shangdong 266510, P. R. China.
Zhihao YuCollege of Energy Storage Technology, Shandong University of Science and Technology, Qingdao, Shangdong 266510, P. R. China.
Feng ShaoQingdao Jinmotang Biotechnology Co., Ltd, Qingdao, Shangdong 266510, P. R. China.
Shandong University of Science and Technology · CNQingdao Center of Resource Chemistry and New Materials · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temporal interference (TI) as a new neuromodulation technique can be applied to non-invasive deep brain stimulation. In order to verify its effectiveness in the regulation of motor behavior in animals, this paper uses the TI method to focus the envelope electric field to the ventral posterior lateral nucleus (VPL) of the thalamus in the deep brain of mouse to regulate left- and right-turning motor behavior. The focusability of TI in the mouse VPL was analyzed by finite element method, and the focus area and volume were obtained by numerical calculation. A stimulator was used to generate TI current to stimulate the mouse VPL to verify the effectiveness of the TI stimulation method, and the accuracy of the focus location was further determined by c-Fos immunofluorescence experiments. The results showed that the electric field generated by TI stimulation was able to focus on the VPL nuclei when the stimulation current reached 800 μA; the mouse were able to make corresponding left and right turns according to the stimulation position; and the c-Fos positive cell markers in the VPL nuclei increased significantly after stimulation. This study confirms the feasibility of TI in regulating animal motor behavior and provides a non-invasive stimulation method for brain tissue for animal robots.

Indexed as

Deep Brain StimulationMotor ActivityProto-Oncogene Proteins c-fosAnimalsBehavior, AnimalFinite Element AnalysisMiceVentral Thalamic NucleiProto-Oncogene Proteins c-fosBehavioral regulationStimulation currentTemporal interferenceVentral posterior lateral nucleus of the thalamus

Identifiers

PMID38686416
PMCPMC11058503
OpenAlexW4396561239

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.