Evidence map›Paper›PMID 38686045›Full record

ReviewOncology research2024

Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier.

Karan Wadhwa, Payal Chauhan, Shobhit Kumar, Rakesh Pahwa, Ravinder Verma, Rajat Goyal, Govind Singh, Archana Sharma, Neha Rao, Deepak Kaushik

Abstract readReview
In one paragraph

Review in Oncology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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  9. Emerging nanoplatforms towards microenvironment-responsive glioma therapy.Medical oncology (Northwood, London, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karan WadhwaDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
Payal ChauhanDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
Shobhit KumarDepartment of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET) NH-58, Delhi-Roorkee Highway, Meerut, 250005, India.
Rakesh PahwaInstitute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, 136119, India.
Ravinder VermaDepartment of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, 127021, India.
Rajat GoyalMM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India.
Govind SinghDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
Archana SharmaDelhi Pharmaceutical Sciences and Research University (DIPSAR), Delhi Pharmaceutical Sciences and Research University, New Delhi, 110017, India.
Neha RaoInstitute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, 136119, India.
Deepak KaushikDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases, for example, PubMed, Science Direct, Google Scholar, and others, using specific keyword combinations, including "glioblastoma," "brain tumor," "nanocarriers," and several others. Conclusion: This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM management. Elucidation of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

Indexed as

Blood-Brain BarrierBrain NeoplasmsDrug CarriersGlioblastomaNanoparticlesAnimalsAntineoplastic AgentsDrug Delivery SystemsHumansAntineoplastic AgentsDrug CarriersBlood-brain barrierBrain tumorGlioblastomaLiposomesMetallic nanoparticlesNanocarriers

Identifiers

PMID38686045
PMCPMC11056000

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.