Evidence map›Paper›PMID 38686042›Full record

ArticleTobacco induced diseases2024

Nicotine aggravates pancreatic fibrosis in mice with chronic pancreatitis via mitochondrial calcium uniporter.

Xue Wei, Yue Yuan, Miaomiao Li, Zhiren Li, Xinye Wang, Haoxuan Cheng, Xinjuan Liu, Jianyu Hao, Tong Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tobacco induced diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xue WeiDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Yue YuanDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Miaomiao LiDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Zhiren LiDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Xinye WangDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Haoxuan ChengDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Xinjuan LiuDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Jianyu HaoDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Tong JinDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to investigate the effects of nicotine on the activation of pancreatic stellate cells (PSCs) and pancreatic fibrosis in chronic pancreatitis (CP), along with its underlying molecular mechanisms.

methodsThis was an

results

conclusionsThis study confirms that nicotine upregulates the expression of MCU, leading to mitochondrial calcium overload and exacerbating oxidative stress in PSCs, and ultimately promoting PSCs activation and exacerbating pancreatic fibrosis in CP.

Indexed as

chronic pancreatitismitochondrial calcium homeostasisnicotineoxidative stresspancreatic stellate cells

Identifiers

PMID38686042
PMCPMC11057042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.