Evidence map›Paper›PMID 38685858›Full record

SynthesisThe American journal of psychiatry2024

Shared and Specific Neural Correlates of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Meta-Analysis of 243 Task-Based Functional MRI Studies.

Hiroki Tamon, Junya Fujino, Takashi Itahashi, Lennart Frahm, Valeria Parlatini, Yuta Y Aoki, Francisco Xavier Castellanos, Simon B Eickhoff, Samuele Cortese

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
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  8. Review
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  11. Article
  12. An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hiroki TamonDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo (Tamon); Graduate School of Medicine and Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan (Tamon); Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Fujino); Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena (Fujino); Medical Institute of Developmental Disabilities Research, Showa University, Tokyo (Itahashi, Aoki); Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany (Frahm, Eickhoff); Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff); Department of Child and Adolescent Psychiatry, King's College London (Parlatini); Aoki Clinic, Tokyo (Aoki); Department of Child and Adolescent Psychiatry, New York University (NYU) Grossman School of Medicine, New York, and Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y. (Castellanos); Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, U.K. (Cortese); Solent National Health System Trust, Southampton, U.K. (Cortese); Hassenfeld Children's Hospital at NYU Langone, NYU Child Study Center, New York (Cortese); Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, U.K. (Cortese); Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy (Cortese).
Junya FujinoDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo (Tamon); Graduate School of Medicine and Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan (Tamon); Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Fujino); Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena (Fujino); Medical Institute of Developmental Disabilities Research, Showa University, Tokyo (Itahashi, Aoki); Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany (Frahm, Eickhoff); Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff); Department of Child and Adolescent Psychiatry, King's College London (Parlatini); Aoki Clinic, Tokyo (Aoki); Department of Child and Adolescent Psychiatry, New York University (NYU) Grossman School of Medicine, New York, and Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y. (Castellanos); Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, U.K. (Cortese); Solent National Health System Trust, Southampton, U.K. (Cortese); Hassenfeld Children's Hospital at NYU Langone, NYU Child Study Center, New York (Cortese); Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, U.K. (Cortese); Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy (Cortese).
Takashi ItahashiDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo (Tamon); Graduate School of Medicine and Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan (Tamon); Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Fujino); Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena (Fujino); Medical Institute of Developmental Disabilities Research, Showa University, Tokyo (Itahashi, Aoki); Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany (Frahm, Eickhoff); Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff); Department of Child and Adolescent Psychiatry, King's College London (Parlatini); Aoki Clinic, Tokyo (Aoki); Department of Child and Adolescent Psychiatry, New York University (NYU) Grossman School of Medicine, New York, and Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y. (Castellanos); Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, U.K. (Cortese); Solent National Health System Trust, Southampton, U.K. (Cortese); Hassenfeld Children's Hospital at NYU Langone, NYU Child Study Center, New York (Cortese); Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, U.K. (Cortese); Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy (Cortese).
Lennart FrahmDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo (Tamon); Graduate School of Medicine and Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan (Tamon); Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Fujino); Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena (Fujino); Medical Institute of Developmental Disabilities Research, Showa University, Tokyo (Itahashi, Aoki); Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany (Frahm, Eickhoff); Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff); Department of Child and Adolescent Psychiatry, King's College London (Parlatini); Aoki Clinic, Tokyo (Aoki); Department of Child and Adolescent Psychiatry, New York University (NYU) Grossman School of Medicine, New York, and Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y. (Castellanos); Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, U.K. (Cortese); Solent National Health System Trust, Southampton, U.K. (Cortese); Hassenfeld Children's Hospital at NYU Langone, NYU Child Study Center, New York (Cortese); Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, U.K. (Cortese); Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy (Cortese).
Valeria ParlatiniDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo (Tamon); Graduate School of Medicine and Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan (Tamon); Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Fujino); Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena (Fujino); Medical Institute of Developmental Disabilities Research, Showa University, Tokyo (Itahashi, Aoki); Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany (Frahm, Eickhoff); Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff); Department of Child and Adolescent Psychiatry, King's College London (Parlatini); Aoki Clinic, Tokyo (Aoki); Department of Child and Adolescent Psychiatry, New York University (NYU) Grossman School of Medicine, New York, and Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y. (Castellanos); Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, U.K. (Cortese); Solent National Health System Trust, Southampton, U.K. (Cortese); Hassenfeld Children's Hospital at NYU Langone, NYU Child Study Center, New York (Cortese); Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, U.K. (Cortese); Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy (Cortese).
Yuta Y AokiDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo (Tamon); Graduate School of Medicine and Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan (Tamon); Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Fujino); Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena (Fujino); Medical Institute of Developmental Disabilities Research, Showa University, Tokyo (Itahashi, Aoki); Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany (Frahm, Eickhoff); Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff); Department of Child and Adolescent Psychiatry, King's College London (Parlatini); Aoki Clinic, Tokyo (Aoki); Department of Child and Adolescent Psychiatry, New York University (NYU) Grossman School of Medicine, New York, and Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y. (Castellanos); Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, U.K. (Cortese); Solent National Health System Trust, Southampton, U.K. (Cortese); Hassenfeld Children's Hospital at NYU Langone, NYU Child Study Center, New York (Cortese); Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, U.K. (Cortese); Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy (Cortese).
Francisco Xavier CastellanosDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo (Tamon); Graduate School of Medicine and Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan (Tamon); Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Fujino); Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena (Fujino); Medical Institute of Developmental Disabilities Research, Showa University, Tokyo (Itahashi, Aoki); Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany (Frahm, Eickhoff); Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff); Department of Child and Adolescent Psychiatry, King's College London (Parlatini); Aoki Clinic, Tokyo (Aoki); Department of Child and Adolescent Psychiatry, New York University (NYU) Grossman School of Medicine, New York, and Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y. (Castellanos); Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, U.K. (Cortese); Solent National Health System Trust, Southampton, U.K. (Cortese); Hassenfeld Children's Hospital at NYU Langone, NYU Child Study Center, New York (Cortese); Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, U.K. (Cortese); Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy (Cortese).
Simon B EickhoffDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo (Tamon); Graduate School of Medicine and Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan (Tamon); Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Fujino); Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena (Fujino); Medical Institute of Developmental Disabilities Research, Showa University, Tokyo (Itahashi, Aoki); Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany (Frahm, Eickhoff); Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff); Department of Child and Adolescent Psychiatry, King's College London (Parlatini); Aoki Clinic, Tokyo (Aoki); Department of Child and Adolescent Psychiatry, New York University (NYU) Grossman School of Medicine, New York, and Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y. (Castellanos); Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, U.K. (Cortese); Solent National Health System Trust, Southampton, U.K. (Cortese); Hassenfeld Children's Hospital at NYU Langone, NYU Child Study Center, New York (Cortese); Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, U.K. (Cortese); Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy (Cortese).
Samuele CorteseDivision of Infant and Toddler Mental Health, Department of Psychosocial Medicine, National Center for Child Health and Development, Tokyo (Tamon); Graduate School of Medicine and Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Miyagi, Japan (Tamon); Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Fujino); Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena (Fujino); Medical Institute of Developmental Disabilities Research, Showa University, Tokyo (Itahashi, Aoki); Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany (Frahm, Eickhoff); Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Eickhoff); Department of Child and Adolescent Psychiatry, King's College London (Parlatini); Aoki Clinic, Tokyo (Aoki); Department of Child and Adolescent Psychiatry, New York University (NYU) Grossman School of Medicine, New York, and Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y. (Castellanos); Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, and Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, U.K. (Cortese); Solent National Health System Trust, Southampton, U.K. (Cortese); Hassenfeld Children's Hospital at NYU Langone, NYU Child Study Center, New York (Cortese); Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, U.K. (Cortese); Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy (Cortese).

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
NIMH NIH HHS R01 MH074457
6 · The paper itself

Abstract

objectiveTo investigate shared and specific neural correlates of cognitive functions in attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), the authors performed a comprehensive meta-analysis and considered a balanced set of neuropsychological tasks across the two disorders.

methodsA broad set of electronic databases was searched up to December 4, 2022, for task-based functional MRI studies investigating differences between individuals with ADHD or ASD and typically developing control subjects. Spatial coordinates of brain loci differing significantly between case and control subjects were extracted. To avoid potential diagnosis-driven selection bias of cognitive tasks, the tasks were grouped according to the Research Domain Criteria framework, and stratified sampling was used to match cognitive component profiles. Activation likelihood estimation was used for the meta-analysis.

resultsAfter screening 20,756 potentially relevant references, a meta-analysis of 243 studies was performed, which included 3,084 participants with ADHD (676 females), 2,654 participants with ASD (292 females), and 6,795 control subjects (1,909 females). ASD and ADHD showed shared greater activations in the lingual and rectal gyri and shared lower activations in regions including the middle frontal gyrus, the parahippocampal gyrus, and the insula. By contrast, there were ASD-specific greater and lower activations in regions including the left middle temporal gyrus and the left middle frontal gyrus, respectively, and ADHD-specific greater and lower activations in the amygdala and the global pallidus, respectively.

conclusionsAlthough ASD and ADHD showed both shared and disorder-specific standardized neural activations, disorder-specific activations were more prominent than shared ones. Functional brain differences between ADHD and ASD are more likely to reflect diagnosis-related pathophysiology than bias from the selection of specific neuropsychological tasks.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderMagnetic Resonance ImagingBrainFemaleHumansMaleNeuropsychological TestsActivation Likelihood EstimationAttention Deficit Hyperactivity Disorder (ADHD)Autism Spectrum Disorder (ASD)Neurodevelopmental DisordersNeuropsychological TaskTask-Based Functional Magnetic Resonance Imaging

Identifiers

PMID38685858
PMCPMC13290293

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.