Evidence map›Paper›PMID 38685845›Full record

ArticleArchives of Iranian medicine2024

EBV-Associated Gastric Cancer; An In Situ Hybridization Assay on Tissue Microarray: A Multi-Region Study from Four Major Provinces of Iran.

Maryam Abolhasani, Ata Ollah Mohseni, Ramin Shakeri, Ali Khavanin, Mehrdad Khajehei, Abbasali Omidi, Bita Geramizadeh, Ensieh Shafigh, Farshad Naghshvar, Payam Fathizadeh and 7 more

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Article in Archives of Iranian medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maryam AbolhasaniOncopathology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-3046-5429
Ata Ollah MohseniDr Mohseni's Pathobiology Laboratory, Nour, Iran.
Ramin ShakeriDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ali KhavaninEmergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mehrdad KhajeheiShiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Abbasali OmidiDepartment of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran.
Bita GeramizadehDepartment of Pathology, Transplantation Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ensieh ShafighDepartment of Pathology, Babol University of Medical Sciences, Babol, Iran.
Farshad NaghshvarDepartment of Pathology, Mazandaran University of Medical Sciences, Sari, Iran.
Payam FathizadehDepartment of Pathology and Laboratory Medicine, Apadana Hospital, Ahvaz, Iran.
Leyla TaghizadehganTaghizadegan's Pathology and Laboratory Medicine, Shiraz, Iran.
Atoosa GharibDepartment of Pathology, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Margaret L GulleyDepartment of Pathology, University of North Carolina, Chapel Hill, NC, USA.
Sanford M DawseyMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Reza MalekzadehDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Charles S RabkinInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-0053-3806
Mohammad VaseiGene Therapy Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-4162-136X

Funding

Molecular mechanisms of infection-related cancerZIACP010212 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ENGELS, ERIC A · 2010 to 2025
$4.6M
6 · The paper itself

Abstract

backgroundGastric cancer is the fourth leading cause of cancer-related deaths in the world. The identification of gastric cancer subtypes related to recognizable microbial agents may play a pivotal role in the targeted prevention and treatment of this cancer. The current study is conducted to define the frequency of Epstein-Barr virus (EBV) infection in gastric cancers of four major provinces, with different incidence rates of gastric cancers, in Iran.

methodsParaffin blocks of 682 cases of various types of gastric cancer from Tehran, South and North areas of Iran were collected. Twelve tissue microarray (TMA) blocks were constructed from these blocks. Localization of EBV in tumors was assessed by in situ hybridization (ISH) for EBV-encoded RNA (EBER). Chi-squared test was used to evaluate the statistical significance between EBV-associated gastric cancer (EBVaGC) and clinicopathologic tumor characteristics.

resultsFourteen out of 682 cases (2.1%) of gastric adenocarcinoma were EBER-positive. EBER was positive in 8 out of 22 (36.4%) of medullary carcinomas and 6 out of 660 (0.9%) of non-medullary type, which was a statistically significant difference (

conclusionEBV-associated gastric adenocarcinoma has a low prevalence in Iran. This finding can be due to epidemiologic differences in risk factors and exposures, and the low number of gastric medullary carcinomas in the population. It may also be related to gastric tumor heterogeneity not detected with the TMA technique.

Indexed as

AdenocarcinomaEpstein-Barr Virus InfectionsHerpesvirus 4, HumanIn Situ HybridizationStomach NeoplasmsTissue Array AnalysisAdultAgedAged, 80 and overFemaleHumansIranMaleMiddle AgedRNA, ViralRNA, ViralEpstein-Barr virusGastric cancerIranTissue microarray

Identifiers

PMID38685845
PMCPMC11097306

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