Evidence map›Paper›PMID 38685774›Full record

ReviewCurrent medicinal chemistry2025

Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders.

Xiaoling Chen, Ting Lu, Ying Zheng, Zhiyong Lin, Chaoqi Liu, Ding Yuan, Chengfu Yuan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoling ChenHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Three Gorges University, Yichang, 443002, China.
Ting LuHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Three Gorges University, Yichang, 443002, China.
Ying ZhengHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Three Gorges University, Yichang, 443002, China.
Zhiyong LinHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Three Gorges University, Yichang, 443002, China.
Chaoqi LiuHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Three Gorges University, Yichang, 443002, China.
Ding YuanCollege of Medicine and Health Science, China Three Gorges University, Yichang, 443002, China.
Chengfu YuanCollege of Basic Medical Science, China Three Gorges University, Yichang, 443002, China.

Funding

innovational group project of Hubei Province Natural Science Foundation in China 2021CFA015National Natural Science Foundation of China 82174035, 82374107, 81974528, 81773959Open Foundation for Tumor Microenvironment and Immunotherapy Key Laboratory of Hubei province in China 2023KZL01
6 · The paper itself

Abstract

backgroundMiR-136-5p plays a vital function in regulating developmental processes as well as in the pathophysiology of diseases, with a notable record in tumor suppression.

methodsThis article summarizes the latest findings on the physiological and pathophysiological processes of miR-136-5p in diseases. We searched for relevant studies and selected research articles from the last five years on PubMed with miR-136-5p as the keyword.

resultsMiR-136-5p represents a class of microRNAs (miRNAs) that are involved in various human maladies, encompassing cancers, cardio-cerebrovascular disease, diabetes, inflammatory disease, tuberous sclerosis, idiopathic pulmonary fibrosis, and polycystic ovary syndrome. Altered expression of miR-136-5p in specific ailments results in downstream gene expression imbalance, influencing cellular behaviors, such as migration, proliferation, and invasion. Furthermore, miR-136-5p is implicated in five signaling pathways, where it is critical in the onset and advancement of a number of illnesses. Additionally, it has the potential to promote drug resistance to a variety of medications.

conclusionThe current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.

Indexed as

MicroRNAsNeoplasmsHumansSignal TransductionMicroRNAsMIRN136 microRNA, humanbioinformaticscancergene expression.inflammationMiR-136-5psignaling pathway

Identifiers

PMID38685774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.