Evidence map›Paper›PMID 38685758›Full record

ArticleThe Journal of physiology2025

Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions.

Guillaume P Ducrocq, Laura Anselmi, Victor Ruiz-Velasco, Marc P Kaufman

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guillaume P DucrocqHeart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-3531-4678
Laura AnselmiHeart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0001-8558-1155
Victor Ruiz-VelascoHeart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-3614-5028
Marc P KaufmanHeart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.

Funding

Opioid-induced potentiation of the exercise pressor reflex via acid-sensing ion channels (ASIC3) in health and simulated peripheral artery diseaseR01HL156513 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI RUIZ-VELASCO, VICTOR · 2021 to 2024
$2.4M
Role played by Acid Ion Sensing Channels in Peripheral Artery DiseaseR01HL156594 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER, RUIZ-VELASCO, VICTOR · 2021 to 2024
$2.3M
Signaling pathways regulating mechanoreflex sensitization in cardiovascular diseaseR01HL161160 · NHLBI · KANSAS STATE UNIVERSITY · PI COPP, STEVEN W · 2022 to 2025
$2.1M
NHLBI NIH HHS R01 HL156513NHLBI NIH HHS R01 HL156594NHLBI NIH HHS R01 HL161160
6 · The paper itself

Abstract

We investigated the role played by lactate and hydrogen in evoking the exercise pressor reflex (EPR) in decerebrated rats whose hindlimb muscles were either freely perfused or ischaemic. Production of lactate and hydrogen by the contracting hindlimb muscles was manipulated by knocking out the myophosphorylase gene (pygm). In knockout rats (pygm

Indexed as

HydrogenIschemiaLactic AcidMuscle ContractionMuscle, SkeletalPhysical Conditioning, AnimalReflexAnimalsBlood PressureHindlimbHydrogen-Ion ConcentrationMaleRatsRats, Sprague-DawleySympathetic Nervous SystemHydrogenLactic Acidacidosisautonomic regulationexerciseexercise pressor reflexmechanoreflexmetaboreflexmyophosphorylase deficiency

Identifiers

PMID38685758
PMCPMC11518877

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.