Evidence map›Paper›PMID 38685733›Full record

ArticleKorean journal of radiology2024

Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy.

Yubo Guo, Xiao Li, Yajuan Gao, Kaini Shen, Lu Lin, Jian Wang, Jian Cao, Zhuoli Zhang, Ke Wan, Xi Yang Zhou and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Korean journal of radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Imaging Advances in Light Chain Amyloidosis.Diagnostics (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Yubo GuoDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0009-0009-7632-2667
Xiao LiDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yajuan GaoDepartment of Hematology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Kaini ShenDepartment of Hematology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lu LinDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0002-3261-6569
Jian WangDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jian CaoDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhuoli ZhangDepartment of Radiological Sciences, University of California, Irvine, CA, USA.
Ke WanDepartment of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Xi Yang ZhouDepartment of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Yucheng ChenDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
Long Jiang ZhangDepartment of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.ORCID 0000-0002-6664-7224
Jian LiDepartment of Hematology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. lijian@pumch.cn.ORCID 0000-0002-4549-0694
Yining WangDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. wangyining@pumch.cn.ORCID 0000-0001-6441-2002
Chinese Academy of Medical Sciences & Peking Union Medical College · CNNanjing General Hospital of Nanjing Military Command · CNSichuan University · CNUniversity of California, Irvine · US

Funding

National High Level Hospital Clinical Research 2022-PUMCH-B-027National High Level Hospital Clinical Research 2022-PUMCH-D-002NNSFC 82020108018NNSFC 82202134NNSFC 82325026
6 · The paper itself

Abstract

objectiveCardiac magnetic resonance (CMR) is a diagnostic tool that provides precise and reproducible information about cardiac structure, function, and tissue characterization, aiding in the monitoring of chemotherapy response in patients with light-chain cardiac amyloidosis (AL-CA). This study aimed to evaluate the feasibility of CMR in monitoring responses to chemotherapy in patients with AL-CA. MATERIALS AND

methodsIn this prospective study, we enrolled 111 patients with AL-CA (50.5% male; median age, 54 [interquartile range, 49-63] years). Patients underwent longitudinal monitoring using biomarkers and CMR imaging. At follow-up after chemotherapy, patients were categorized into superior and inferior response groups based on their hematological and cardiac laboratory responses to chemotherapy. Changes in CMR findings across therapies and differences between response groups were analyzed.

resultsFollowing chemotherapy (before vs. after), there were significant increases in myocardial T2 (43.6 ± 3.5 ms vs. 44.6 ± 4.1 ms;

conclusionCardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.

Indexed as

CardiomyopathiesAmyloidosisAntineoplastic AgentsFeasibility StudiesFemaleHumansImmunoglobulin Light-chain AmyloidosisMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMiddle AgedProspective StudiesTreatment OutcomeAntineoplastic AgentsAmyloidosisCardiac magnetic resonanceChemotherapyLongitudinal strainTissue characterization

Identifiers

PMID38685733
PMCPMC11058424
OpenAlexW4395462067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.