Observational studyCardiovascular diabetology2024
The prognostic impact of insulin resistance surrogates in patients with acute myocardial infarction with and without type 2 diabetes.
Observational study in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 25 citations in OpenAlex.
- Association of the Triglyceride-Glucose Index with Premature Myocardial Infarction in a Propensity Score-Matched Non-Diabetic Population.Diagnostics (Basel, Switzerland) · 2026Article
- Integrated Assessment of Stress Hyperglycemia and Glycemic Variability for Mortality Prediction in Non-St-Segment Elevation Myocardial Infarction and St-Segment Elevation Myocardial Infarction: A Glycometabolic Phenotype-Stratified Analysis.Reviews in cardiovascular medicine · 2026Article
- Association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with atherosclerotic cardiovascular diseases: a retrospective cohort study using the MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- Article
- Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: evidence from international multi-cohort studies.Cardiovascular diabetology · 2026Article
- Elevated angiography-derived microvascular resistance and HbA1c levels jointly predict adverse outcomes in patients with diabetic STEMI: a multicenter retrospective cohort study.Frontiers in endocrinology · 2026Observational
- Cumulative triglyceride-glucose-body mass index exposure and cardiovascular disease risk: findings from the Kailuan study.Frontiers in cardiovascular medicine · 2026Article
- The association between insulin resistance indices and the occurrence of major adverse cardiovascular events in patients with premature myocardial infarction: a prospective cohort study.Frontiers in nutrition · 2026Article
- Integration of 2D Speckle Tracking Strain and Clinical Indicators for Early Prediction of Post-PCI Heart Failure in Patients with STEMI and Type 2 Diabetes.International journal of general medicine · 2026Article
- Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- The Association of C-Reactive Protein-Triglyceride Glucose Index with Major Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction.Journal of inflammation research · 2026Article
- METS-VF and METS-IR as predictors of acute myocardial infarction in U.S. adults: Evidence from NHANES 2005 to 2018.Medicine · 2025Article
- Association of insulin resistance indices with outcomes after endovascular treatment in acute basilar artery occlusion.Lipids in health and disease · 2025Article
- Comparative analysis of insulin resistance indicators in predicting reversion from prediabetes to normoglycemia.Diabetology & metabolic syndrome · 2025Article
- Metabolic score for insulin resistance is associated with adverse cardiovascular events in patients with type 2 diabetes.World journal of diabetes · 2025Article
- Association of incidence of colorectal polyp with markers of insulin resistance and other related factors: a cross-sectional study.Scientific reports · 2025Article
- Article
- Association of overactive bladder with all-cause and cardiovascular mortality in women: A propensity-matched NHANES study.BJUI compass · 2025Article
- Association between the triglyceride-glucose index and silent myocardial infarction in the general population.Scientific reports · 2025Article
- Associations of triglyceride glucose-body mass index and the combination of sedentary behavior and physical activity with risks of all-cause mortality and myocardial infarction: a cohort study from the UK biobank.Cardiovascular diabetology · 2025Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular disease is the major cause of morbidity and mortality, particularly in type 2 diabetes mellitus (T2DM). Novel markers of insulin resistance and progression of atherosclerosis include the triglycerides and glucose index (TyG index), the triglycerides and body mass index (Tyg-BMI) and the metabolic score for insulin resistance (METS-IR). Establishing independent risk factors for in-hospital death and major adverse cardiac and cerebrovascular events (MACCE) in patients with myocardial infarction (MI) remains critical. The aim of the study was to assess the risk of in-hospital death and MACCE within 12 months after ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) in patients with and without T2DM based on TyG index, Tyg-BMI and METS-IR.
methodsRetrospective analysis included 1706 patients with STEMI and NSTEMI hospitalized between 2013 and 2021. We analyzed prognostic value of TyG index, Tyg-BMI and METS-IR for in-hospital death and MACCE as its components (death from any cause, MI, stroke, revascularization) within 12 months after STEMI or NSTEMI in patients with and without T2DM.
resultsOf 1706 patients, 58 in-hospital deaths were reported (29 patients [4.3%] in the group with T2DM and 29 patients [2.8%] in the group without T2DM; p = 0.1). MACCE occurred in 18.9% of the total study population (25.8% in the group with T2DM and 14.4% in the group without T2DM; p < 0.001). TyG index, Tyg-BMI and METS-IR were significantly higher in the group of patients with T2DM compared to those without T2DM (p < 0.001). Long-term MACCE were more prevalent in patients with T2DM (p < 0.001). The area under the ROC curve (AUC-ROC) for the prediction of in-hospital death and the TyG index was 0.69 (p < 0.001). The ROC curve for predicting in-hospital death based on METS-IR was 0.682 (p < 0.001). The AUC-ROC values for MACCE prediction based on the TyG index and METS-IR were 0.582 (p < 0.001) and 0.57 (p < 0.001), respectively.
conclusionsTyG index was an independent risk factor for in-hospital death in patients with STEMI or NSTEMI. TyG index, TyG-BMI and METS-IR were not independent risk factors for MACCE at 12 month follow-up. TyG index and METS-IR have low predictive value in predicting MACCE within 12 months after STEMI and NSTEMI.
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