Evidence map›Paper›PMID 38685048›Full record

ArticleParasites & vectors2024

Efficacy of monthly treatment with oral fluralaner (Bravecto

Katharine Costa Dos Santos, Paula Elisa Brandão Guedes, George Rêgo Albuquerque, Anderson Vieira de Jesus, Anaiá da Paixão Sevá, Joana Thaisa Santos de Oliveira, Jamille Bispo de Carvalho Teixeira, Thammy Vieira Bitar, Tatiani Vitor Harvey, Sofia Nadir Sanches Ramos and 3 more

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Katharine Costa Dos SantosDepartment of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, UESC, State University of Santa Cruz, Rod. Jorge Amado Km 16-Salobrinho, Ilhéus, Bahia, 45662-900, Brazil.
Paula Elisa Brandão GuedesDepartment of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, UESC, State University of Santa Cruz, Rod. Jorge Amado Km 16-Salobrinho, Ilhéus, Bahia, 45662-900, Brazil.
George Rêgo AlbuquerqueDepartment of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, UESC, State University of Santa Cruz, Rod. Jorge Amado Km 16-Salobrinho, Ilhéus, Bahia, 45662-900, Brazil.
Anderson Vieira de JesusDepartment of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, UESC, State University of Santa Cruz, Rod. Jorge Amado Km 16-Salobrinho, Ilhéus, Bahia, 45662-900, Brazil.
Anaiá da Paixão SeváDepartment of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, UESC, State University of Santa Cruz, Rod. Jorge Amado Km 16-Salobrinho, Ilhéus, Bahia, 45662-900, Brazil.
Joana Thaisa Santos de OliveiraDepartment of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, UESC, State University of Santa Cruz, Rod. Jorge Amado Km 16-Salobrinho, Ilhéus, Bahia, 45662-900, Brazil.
Jamille Bispo de Carvalho TeixeiraDepartment of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, UESC, State University of Santa Cruz, Rod. Jorge Amado Km 16-Salobrinho, Ilhéus, Bahia, 45662-900, Brazil.
Thammy Vieira BitarDepartment of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, UESC, State University of Santa Cruz, Rod. Jorge Amado Km 16-Salobrinho, Ilhéus, Bahia, 45662-900, Brazil.
Tatiani Vitor HarveyTexas A&M University, College Station, 400 Bizzell St., TX 77843, TX, USA.
Sofia Nadir Sanches RamosMSD, Merck & Co Animal Health, Avenida Doutor Chucri Zaidan, 296, 12º Andar, São Paulo, 04583-110, Brazil.
Francisco Bonomi BarufiMSD, Merck & Co Animal Health, Avenida Doutor Chucri Zaidan, 296, 12º Andar, São Paulo, 04583-110, Brazil.
Fernando de Almeida BorgesFaculty of Veterinary Medicine and Zootechnics, UFMS, Federal University of Mato Grosso Do Sul, Campo Grande, Mato Grosso Do Sul, Brazil.
Renata Santiago Alberto CarlosDepartment of Agricultural and Environmental Sciences, Postgraduate Program in Animal Science, UESC, State University of Santa Cruz, Rod. Jorge Amado Km 16-Salobrinho, Ilhéus, Bahia, 45662-900, Brazil. rsacarlos@uesc.br.
Universidade Estadual de Santa Cruz · BRTexas A&M University · USUniversidade Federal de Mato Grosso do Sul · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

backgroundTungiasis is a neglected tropical disease caused by the adult female sand flea (Tunga penetrans). Dogs are considered important reservoirs of T. penetrans in Brazil. The aim of this study was to determine the monthly insecticidal efficacy of a single oral administration of fluralaner at a dose of 10-18 mg/kg (Bravecto

methodsThis clinical trial was conducted in a rural community located in Ilhéus, Bahia, Brazil. A total of 64 dogs were selected and distributed in a completely randomized design between a treated group (TG) that received one single dose of Bravecto

resultsThe primary efficacy of the product was greater than 95.0% from days 7 to 21 and reached 100.0% between days 28 and 42, with a significant association between treatment and infestation decline (P < 0.025) between days 7 and 42. Secondary drug efficacy was greater than 99.9% from days 7 to 21, reaching 100.0% between days 28 and 42 (P < 0.05). The treated dogs also scored lower on the SCADT than the control animals did during the entire clinical evaluation period (P < 0.05).

conclusionsA single administration of Bravecto

Indexed as

Dog DiseasesInsecticidesIsoxazolesTungaTungiasisAdministration, OralAnimalsBrazilDogsDouble-Blind MethodFemaleMaleTreatment OutcomeA1443 compoundInsecticidesIsoxazolesCanine tungiasisEctoparasitosisRural communitiesTreatmentZoonosis

Identifiers

PMID38685048
PMCPMC11059606
OpenAlexW4396230702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.