Evidence map›Paper›PMID 38685035›Full record

Trial reportBMC oral health2024

Evaluation and comparison of the effects of a new paste containing 8% L-Arginine and CaCO3 plus KNO3 on dentinal tubules occlusion and dental sensitivity: a randomized, triple blinded clinical trial study.

Hamideh Sadat Mohammadipour, Hossein Bagheri, Saber Babazadeh, Mehrzad Khorshid, Zahra Shooshtari, Arsalan Shahri

Open access · goldAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hamideh Sadat MohammadipourDepartment of Restorative and Cosmetic Dentistry, Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID http://orcid.org/0000-0001-8160-6239
Hossein BagheriDental Materials Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID http://orcid.org/0000-0003-1269-7434
Saber BabazadehDepartment of Community Oral Health, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID http://orcid.org/0000-0002-5431-6479
Mehrzad KhorshidIndependent Researcher, Mashhad, Iran.ORCID http://orcid.org/0000-0003-4835-8872
Zahra ShooshtariDentist, Research Assistant, Dental Research Center, Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID http://orcid.org/0000-0003-4469-2769
Arsalan ShahriDental Materials Research Center, Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran. Arsalshahri98@gmail.com.ORCID http://orcid.org/0000-0002-0980-7797
Mashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDentin hypersensitivity, often occurring after dental treatments or from erosive lesions, is a prevalent patient complaint. This study introduces a paste combining 8% L-arginine, calcium carbonate, and potassium nitrate to evaluate its impact on dentinal tubules occlusion, dentin permeability, and tooth sensitivity.

methodsDentin surfaces from 24 third molars (thickness: 2 mm) were divided into two groups of 12. One received the experimental paste, while the other received a placebo without desensitizer. Permeability and sealing ability were assessed through scanning electron microscopy (SEM) and dentin permeability measurement. The pastes' effects on hypersensitivity were then examined in a triple-blind, randomized parallel-armed clinical trial with 16 eligible patients. Sensitivity to cold, touch, and spontaneous stimuli was recorded using the VAS scale at various intervals post-treatment. Statistical analysis was conducted using Shapiro-Wilk, Mann-Whitney U, Friedman, and Wilcoxon tests (α = 0.05).

resultsThe permeability test demonstrated a significant reduction in dentin permeability in the experimental group (P = 0.002) compared to the control (P = 0.178). SEM images revealed most dentinal tubules in the intervention samples to be occluded. Clinically, both groups showed a significant decrease in the three types of evaluated sensitivity throughout the study. However, no significant difference in sensitivities between the two groups was observed, with the exception of cold sensitivity at three months post-treatment (P = 0.054).

conclusionThe innovative desensitizing paste featuring 8% L-arginine, calcium carbonate, and potassium nitrate effectively occluded dentinal tubules and reduced dentin permeability. It mitigated immediate and prolonged dentin hypersensitivity to various stimuli, supporting its potential role in managing dentin hypersensitivity.

trial registrationhttp://irct.ir : IRCT20220829055822N1, September 9th, 2022.

Indexed as

ArginineCalcium CarbonateDentin Desensitizing AgentsDentin SensitivityMicroscopy, Electron, ScanningNitratesPotassium CompoundsAdultDentinDentin PermeabilityFemaleHumansMaleMiddle AgedToothpastesYoung AdultArginineCalcium CarbonateDentin Desensitizing AgentsNitratesPotassium Compoundspotassium nitrateToothpastesArginineCalcium carbonateDentin permeabilityPotassium nitrateTooth sensitivity

Identifiers

PMID38685035
PMCPMC11059626
OpenAlexW4396220216

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.