Evidence map›Paper›PMID 38685026›Full record

ArticleJournal of translational medicine2024

Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases.

Jie Wen, Jingwei Zhang, Hao Zhang, Nan Zhang, Ruoyan Lei, Yujia Deng, Quan Cheng, He Li, Peng Luo

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
18.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  13. Prolonged exposure to leisure screen time notably accelerates biological aging: Evidence from observational studies and genetic associations.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Observational
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  20. Probabilistic human health risk assessment of PMFrontiers in public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jie Wen *The Animal Laboratory Center, Hunan Cancer Hospital, and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Jingwei Zhang *Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Hao ZhangDepartment of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Nan ZhangCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Ruoyan LeiXiangya School of Medicine, Central South University, Changsha, China.
Yujia DengDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Quan ChengDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China. chengquan@csu.edu.cn.ORCID 0000-0003-2401-5349
He LiThe Animal Laboratory Center, Hunan Cancer Hospital, and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. lihe@hnca.org.cn.
Peng LuoDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. luopeng@smu.edu.cn.
Central South University · CNDalian Medical University · CNHuazhong University of Science and Technology · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiological evidence links a close correlation between long-term exposure to air pollutants and autoimmune diseases, while the causality remained unknown.

methodsTwo-sample Mendelian randomization (TSMR) was used to investigate the role of PM10, PM2.5, NO

resultsIn TSMR, after correction of multiple testing, hypothyroidism was causally associated with higher exposure to NO

conclusionThis research underscores the necessity of rigorous air pollutant surveillance within public health studies to curb the prevalence of autoimmune diseases.

Indexed as

Air PollutantsAutoimmune DiseasesGenome-Wide Association StudyGenetic Predisposition to DiseaseHumansMendelian Randomization AnalysisParticulate MatterAir PollutantsParticulate MatterAir pollutantsAutoimmune diseaseCausal relationshipMendelian randomizationTWAS

Identifiers

PMID38685026
PMCPMC11057084
OpenAlexW4396235339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.