ArticleEMBO reports2024
Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.
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Article in EMBO reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen.Cell reports · 2026Article
- Dysregulated neuronal mRNA transport and translation in FTD/ALS.NPJ dementia · 2026Review
- Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review).International journal of molecular medicine · 2026Review
- PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease.Acta neuropathologica · 2025Article
- A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests 'space cadet syndrome' on two FVB backgrounds.Disease models & mechanisms · 2025Article
- GCN2 inhibition reduces mutant SOD1 clustering and toxicity and delays disease progression in an amyotrophic lateral sclerosis mouse model.Translational neurodegeneration · 2024Article
Corrections and comments
- Update of
Authors and funding
11 authors.
Andrew T Nelson *Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Maria Elena Cicardi *Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.ORCID 0000-0001-9490-303X
Shashirekha S MarkandaiahWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
John Ys HanDepartment of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Nancy J PhilpDepartment of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA.ORCID 0000-0001-7028-0448
Emily WelebobWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Aaron R HaeuslerWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.ORCID 0000-0001-5566-3707
Piera PasinelliWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Giovanni ManfrediFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY, 10065, USA.ORCID 0000-0003-3893-1348
Hibiki KawamataFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY, 10065, USA.ORCID 0000-0003-0020-6933
Davide TrottiWeinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA. davide.trotti@jefferson.edu.ORCID 0000-0001-6338-6404
Funding
Mitochondrial Integrated Stress Response in Neurological DiseasesR35NS122209 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Giovanni Manfredi · 2021 to 2026
$6.6MExosome-mediated propagation of disease linked poly-dipeptides in C9orf72-FTD/ALSRF1AG057882 · NIA · THOMAS JEFFERSON UNIVERSITY · PI TROTTI, DAVIDE, YANG, YONGJIE · 2018 to 2018
$3.6MThe pathogenic relationship between neuronal activity and C9orf72-linked neurodegenerationRF1NS114128 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI HAEUSLER, AARON RAYMOND · 2020 to 2021
$2.5MContribution of astrocytes to mutant FUS-linked Amyotrophic Lateral SclerosisR01NS109150 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI PASINELLI, PIERA · 2019 to 2023
$1.7MDevelopment of a mouse model of C9ORF72 ALS/FTD expressing RAN translated peptideR21NS090912 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI TROTTI, DAVIDE · 2014 to 2015
$428kMetabolic perturbations as a modifier of repeat-associated non-AUG translation in C9orf72-linked ALS/FTDF31NS118838 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI NELSON, ANDREW · 2020 to 2021
$92kDOD | USA | MEDCOM | MRDC | U.S. Army Medical Research Acquisition Activity (USAMRAA) W81XWH-21-1-0134HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) F31-NS118838HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R21-NS090912HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RF1-NS114128HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RO1-NS109150HHS | NIH | National Institute on Aging (NIA) RF1-AG057882Muscular Dystrophy Association (MDA) 628389NIA NIH HHS RF1 AG057882NINDS NIH HHS F31 NS118838NINDS NIH HHS R01 NS109150NINDS NIH HHS R21 NS090912NINDS NIH HHS R35 NS122209NINDS NIH HHS RF1 NS114128
Abstract
The most prevalent genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia is a (GGGGCC)
Indexed as
Amyotrophic Lateral SclerosisC9orf72 ProteinFrontotemporal DementiaGlucosePhenotyperan GTP-Binding ProteinAdenosine TriphosphateAnimalsBrainDisease Models, AnimalDNA Repeat ExpansionMiceMice, TransgenicNeuronsProtein BiosynthesisAdenosine TriphosphateC9orf72 ProteinGlucoseran GTP-Binding ProteinRan protein, mouseALSC9orf72FTDGlucose HypometabolismRAN Translation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.