Evidence map›Paper›PMID 38684809›Full record

ArticleNature nanotechnology2024

Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells.

Kristel J Yee Mon, Sungwoong Kim, Zhonghao Dai, Jessica D West, Hongya Zhu, Ritika Jain, Andrew Grimson, Brian D Rudd, Ankur Singh

Abstract read
In one paragraph

Article in Nature nanotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Ultrasonic-activated LaFundamental research · 2026
    Article
  4. Article
  5. Article
  6. Poking Pluripotency: Nanoinjection Into Human iPSCs.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Polymeric nanocarriers for therapeutic gene delivery.Asian journal of pharmaceutical sciences · 2025
    Review
  16. Biomaterial-Based Therapeutic Delivery of Immune Cells.Advanced healthcare materials · 2025
    Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kristel J Yee Mon *Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0001-7355-4811
Sungwoong Kim *George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Zhonghao DaiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Jessica D WestDepartment of Molecular Biology & Genetics, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-5497-0518
Hongya ZhuDepartment of Molecular Biology & Genetics, Cornell University, Ithaca, NY, USA.
Ritika JainWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-4530-7578
Andrew GrimsonDepartment of Molecular Biology & Genetics, Cornell University, Ithaca, NY, USA.
Brian D RuddDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, USA. bdr54@cornell.edu.ORCID http://orcid.org/0000-0002-9742-8358
Ankur SinghGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. ankur.singh@gatech.edu.ORCID http://orcid.org/0000-0002-3501-2277

Funding

The developmental layers in the CD8+ T cell response to chronic infectionR01AI110613 · NIAID · CORNELL UNIVERSITY · PI GRIMSON, ANDREW W, RUDD, BRIAN DAVID · 2014 to 2022
$4.1M
Hydrogel-based Organoids of African-American Lymphomas to Study B Cell Receptor Pathway InhibitorsR01CA266052 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI JEAN L KOFF, Ankur Singh · 2022 to 2026
$2.7M
Lymphoid Experimental Therapeutics Platform to Study Cooperative Signaling inHuman LymphomasR01CA238745 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGH, ANKUR · 2020 to 2024
$2.2M
Roles for DevelopmentallyRegulated microRNAs in Neonatal ImmunityU01AI131348 · NIAID · CORNELL UNIVERSITY · PI GRIMSON, ANDREW W, RUDD, BRIAN DAVID · 2017 to 2021
$2.2M
Dysregulated mechanoimmunology of epigenetics-driven lymphomasU01CA280984 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Ankur Singh, Cheng Zhu · 2023 to 2026
$2.1M
Biomaterials-based Germinal Center Niches for Understanding the B Cell Maturation and B cell receptor signalingR01AI132738 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGH, ANKUR · 2018 to 2022
$1.9M
NCI NIH HHS R01 CA238745NCI NIH HHS R01 CA266052NCI NIH HHS U01 CA280984NIAID NIH HHS R01 AI110613NIAID NIH HHS R01 AI132738NIAID NIH HHS U01 AI131348U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R01CA238745-01A1U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1R01CA266052-01U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI110613U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01AI131348U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01CA280984-01U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 5R01AI132738-06
6 · The paper itself

Abstract

Cellular programming of naïve T cells can improve the efficacy of adoptive T-cell therapy. However, the current ex vivo engineering of T cells requires the pre-activation of T cells, which causes them to lose their naïve state. In this study, cationic-polymer-functionalized nanowires were used to pre-program the fate of primary naïve CD8

Indexed as

CD8-Positive T-LymphocytesMicroRNAsNanowiresAnimalsCells, CulturedCell SurvivalFemaleGene ExpressionHumansMaleMiceTranscriptomeMicroRNAsMIRN130 microRNA, mouse

Identifiers

PMID38684809
PMCPMC11330359

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.