ArticleNature communications2024
Stress-shape misalignment in confluent cell layers.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Extracellular-matrix mediated stresses spatially bias myoblast fusion and myotube growth.Nature communications · 2026Article
- Multi-phase field model reveals internal dissipation is crucial for spontaneous hole formation in cell monolayers.Nature communications · 2026Article
- HB-EGF enhances collective cell migration via spatial coordination of traction.APL bioengineering · 2026Article
- Accessible and cost-effective methods for patterning cell monolayers on compliant substrates.PloS one · 2026Article
- Shaping 3D minimal model tissues with mechanical constraints to orchestrate muscle differentiation.Communications biology · 2025Article
- Traction and Stress Control Formation and Motion of +1/2 Topological Defects in Epithelial Cell Monolayers.Newton ((New York, N.Y.) · 2025Article
- Integer topological defects offer a methodology to quantify and classify active cell monolayers.Nature communications · 2025Article
- Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics.Nature physics · 2025Article
- Strings and topological defects govern ordering kinetics in endothelial cell layers.Nature physics · 2025Article
- Stress-shape misalignment in confluent cell layers.Nature communications · 2024Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In tissue formation and repair, the epithelium undergoes complex patterns of motion driven by the active forces produced by each cell. Although the principles governing how the forces evolve in time are not yet clear, it is often assumed that the contractile stresses within the cell layer align with the axis defined by the body of each cell. Here, we simultaneously measured the orientations of the cell shape and the cell-generated contractile stresses, observing correlated, dynamic domains in which the stresses were systematically misaligned with the cell body. We developed a continuum model that decouples the orientations of contractile stress and cell body. The model recovered the spatial and temporal dynamics of the regions of misalignment in the experiments. These findings reveal that the cell controls its contractile forces independently from its shape, suggesting that the physical rules relating cell forces and cell shape are more flexible than previously thought.
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