Evidence map›Paper›PMID 38684606›Full record

ArticleAnnals of biomedical engineering2024

Controlled Mechanical Property Gradients Within a Digital Light Processing Printed Hydrogel-Composite Osteochondral Scaffold.

Kevin N Eckstein, John E Hergert, Asais Camila Uzcategui, Sarah A Schoonraad, Stephanie J Bryant, Robert R McLeod, Virginia L Ferguson

Abstract read
In one paragraph

Article in Annals of biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kevin N EcksteinPaul M. Rady Department of Mechanical Engineering, University of Colorado at Boulder, 427 UCB, Boulder, CO, 80309, USA.
John E HergertMaterials Science and Engineering Program, University of Colorado at Boulder, Boulder, CO, USA.
Asais Camila UzcateguiMaterials Science and Engineering Program, University of Colorado at Boulder, Boulder, CO, USA.
Sarah A SchoonraadDepartment of Chemical and Biological Engineering, University of Colorado at Boulder, Boulder, CO, USA.
Stephanie J BryantMaterials Science and Engineering Program, University of Colorado at Boulder, Boulder, CO, USA.
Robert R McLeodMaterials Science and Engineering Program, University of Colorado at Boulder, Boulder, CO, USA.
Virginia L FergusonPaul M. Rady Department of Mechanical Engineering, University of Colorado at Boulder, 427 UCB, Boulder, CO, 80309, USA. virginia.ferguson@colorado.edu.ORCID http://orcid.org/0000-0002-8448-4406

Funding

Mechanically Stiff Hydrogels for Osteochondral Tissue EngineeringR01AR069060 · NIAMS · UNIVERSITY OF COLORADO · PI Stephanie J Bryant · 2016 to 2026
$4.1M
Treatment of pediatric physeal injuries using a 3D printed biomimetic of growth plate cartilageR33HD090696 · NICHD · UNIVERSITY OF COLORADO DENVER · PI BRYANT, STEPHANIE J, FERGUSON, VIRGINIA LEA · 2019 to 2021
$1.1M
Treatment of pediatric physeal injuries using a 3D printed biomimetic of growth plate cartilageR21HD090696 · NICHD · UNIVERSITY OF COLORADO DENVER · PI BRYANT, STEPHANIE J, FERGUSON, VIRGINIA LEA · 2017 to 2018
$417k
NIAMS NIH HHS R01 AR069060NICHD NIH HHS R21 HD090696NICHD NIH HHS R33 HD090696
6 · The paper itself

Abstract

Tissue engineered scaffolds are needed to support physiological loads and emulate the micrometer-scale strain gradients within tissues that guide cell mechanobiological responses. We designed and fabricated micro-truss structures to possess spatially varying geometry and controlled stiffness gradients. Using a custom projection microstereolithography (μSLA) system, using digital light projection (DLP), and photopolymerizable poly(ethylene glycol) diacrylate (PEGDA) hydrogel monomers, three designs with feature sizes < 200 μm were formed: (1) uniform structure with 1 MPa structural modulus (

Indexed as

Cartilage, ArticularHydrogelsPolyethylene GlycolsTissue ScaffoldsAnimalsFinite Element AnalysisPrinting, Three-DimensionalTissue EngineeringHydrogelspoly(ethylene glycol)diacrylatePolyethylene Glycols3D printingCartilageCompositeMechanical propertiesOsteochondralScaffold

Identifiers

PMID38684606
PMCPMC11989580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.