Evidence map›Paper›PMID 38684558›Full record

Trial reportEuropean journal of clinical pharmacology2024

Improved adherence to statin treatment and differences in results between men and women after pictorial risk communication-a sub-study of the VIPVIZA RCT.

Henrik Holmberg, Eva-Lotta Glader, Ulf Näslund, Bo Carlberg, Eva Sönnerstam, Margareta Norberg, Anders Själander

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of clinical pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01849575 (Direct VIsualiZAtion of Asymptomatic Atherosclerotic Disease for Optimum Cardiovascular Prevention. A Population Based Pragmatic Randomised Controlled Trial Within Västerbotten Intervention Programme), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01849575 naactive not recruitingnot on this map

Direct VIsualiZAtion of Asymptomatic Atherosclerotic Disease for Optimum Cardiovascular Prevention. A Population Based Pragmatic Randomised Controlled Trial Within Västerbotten Intervention Programme (VIP) and Ordinary Care.

TypeinterventionalSponsorUmeå UniversityRan2013 to 2027Enrolled3,532ConditionsCardiovascular DiseasesArmsIntervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Henrik HolmbergDepartment of Epidemiology and Global Health, Umeå University, 907 36, Umeå, Sweden. Henrik.Holmberg@umu.se.
Eva-Lotta GladerDepartment of Public Health and Clinical Medicine, Umeå University, 907 36, Umeå, Sweden.
Ulf NäslundDepartment of Public Health and Clinical Medicine, Umeå University, 907 36, Umeå, Sweden.
Bo CarlbergDepartment of Public Health and Clinical Medicine, Umeå University, 907 36, Umeå, Sweden.
Eva SönnerstamDepartment of Public Health and Clinical Medicine, Umeå University, 907 36, Umeå, Sweden.
Margareta NorbergDepartment of Public Health and Clinical Medicine, Umeå University, 907 36, Umeå, Sweden.
Anders SjälanderDepartment of Public Health and Clinical Medicine, Umeå University, 907 36, Umeå, Sweden.

Funding

Hjärt-Lungfonden 20150369Vetenskapsrådet 521-2013-2708
6 · The paper itself

Abstract

backgroundPeople with intermediate CVD risk constitute most of the population. Within this group, the proportion of events is lower compared to the high-risk group, but they contribute with the largest absolute number of events. Atherosclerosis is a dynamic process and progression can be slowed or even reversed with medication and lifestyle changes, but adherence to prescribed treatment is crucial.

aimTo investigate the long-term effects of interventions with pictorial risk communication of cardiovascular (CVD) risk on average adherence in a group of statin users. Compare response in adherence over time between men and women after intervention.

methodsParticipants on active statin treatment were followed up to 5 years after being randomly assigned to an intervention program aimed at raising CVD risk awareness among participants and their physicians. Merging prescribed medication databases with VIPVIZA study to study adherence over time. A moving average adherence was used to compare groups.

resultsGenerally, the average adherence to statins among the 512 participants was high. Men had a higher average adherence over time, while women had a sharper increase in adherence in conjuncture with the intervention program.

conclusionsBoth men and women were receptive to pictorial information regarding CVD risk, but the intervention effect was more pronounced in women. Sex differences are important when considering risk communication strategies. Periodically repeating the intervention was beneficial for maintaining the intervention effect over time.

trial registrationThe VIPVIZA study is registered with ClinicalTrials.gov , May 8, 2013, number NCT01849575.

Indexed as

Cardiovascular DiseasesHydroxymethylglutaryl-CoA Reductase InhibitorsMedication AdherenceAgedCommunicationFemaleHumansMaleMiddle AgedPatient Education as TopicSex FactorsHydroxymethylglutaryl-CoA Reductase InhibitorsAtherosclerosisCardiovascular disease preventionCardiovascular riskPictorial informationStatin initiationStatins

Identifiers

PMID38684558
PMCPMC11226488

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.