Evidence map›Paper›PMID 38684528›Full record

ArticleClinical oral investigations2024

The effects of NLRP3 inflammasome inhibition or knockout in experimental apical periodontitis induced in mice.

Carolina Maschietto Pucinelli, Raquel Assed Bezerra da Silva, Paulo Nelson-Filho, Ricardo Barbosa Lima, Marília Pacífico Lucisano, Julie Teresa Marchesan, Léa Assed Bezerra da Silva

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In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carolina Maschietto PucinelliDepartment of Pediatric Dentistry (DCI), School of Dentistry of Ribeirão Preto, University of São Paulo (FORP/USP), Avenida do Café, s/n, Vila Monte Alegre, Ribeirão Preto, São Paulo, Brazil.
Raquel Assed Bezerra da SilvaDepartment of Pediatric Dentistry (DCI), School of Dentistry of Ribeirão Preto, University of São Paulo (FORP/USP), Avenida do Café, s/n, Vila Monte Alegre, Ribeirão Preto, São Paulo, Brazil.
Paulo Nelson-FilhoDepartment of Pediatric Dentistry (DCI), School of Dentistry of Ribeirão Preto, University of São Paulo (FORP/USP), Avenida do Café, s/n, Vila Monte Alegre, Ribeirão Preto, São Paulo, Brazil.
Ricardo Barbosa LimaDepartment of Pediatric Dentistry (DCI), School of Dentistry of Ribeirão Preto, University of São Paulo (FORP/USP), Avenida do Café, s/n, Vila Monte Alegre, Ribeirão Preto, São Paulo, Brazil. ricardobarbosalima@usp.br.
Marília Pacífico LucisanoDepartment of Pediatric Dentistry (DCI), School of Dentistry of Ribeirão Preto, University of São Paulo (FORP/USP), Avenida do Café, s/n, Vila Monte Alegre, Ribeirão Preto, São Paulo, Brazil.
Julie Teresa MarchesanDepartment of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Léa Assed Bezerra da SilvaDepartment of Pediatric Dentistry (DCI), School of Dentistry of Ribeirão Preto, University of São Paulo (FORP/USP), Avenida do Café, s/n, Vila Monte Alegre, Ribeirão Preto, São Paulo, Brazil.

Funding

Inflammasome regulation underlying sexual dimorphism in periodontitisR01DE032830 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Julie Teresa Marchesan · 2023 to 2026
$2.9M
IFI16 is a Periodontitis Modulating ProteinK01DE027087 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARCHESAN, JULIE TERESA · 2017 to 2022
$833k
NIDCR NIH HHS K01 DE027087NIDCR NIH HHS R01 DE032830
6 · The paper itself

Abstract

objectiveTo evaluate the effects of NLRP3 inflammasome inhibition or knockout in experimental apical periodontitis (AP) induced in mice.

methodsThe experimental AP was induced by pulpal exposure. To evaluate NLRP3-specific inhibitor medication (MCC950), WT mice received intraperitoneal injections, while the control received PBS (n = 10). In addition, to evaluate NLRP3 knockout, 35 wild-type (WT) and 35 NLRP3

resultsExposure to MCC950 did not affect the periapical lesion size after 14 days (P = 0.584). However, exposed mice had a lower expression of IL-1β, IL-18 and caspase-1 (P = 0.010, 0.016 and 0.002, respectively). Moreover, NLRP3

conclusionsNLRP3 inflammasome inhibition or knockout can attenuate the inflammatory events that result in the periapical lesion (AP) formation after pulpal exposure in mice. CLINICAL RELEVANCE: The NLRP3 inflammasome may be a therapeutic target for AP, and new approaches may verify the impact of its inhibition (through intracanal medications or filling materials) on the bone repair process and treatment success.

Indexed as

Disease Models, AnimalIndenesInflammasomesMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinPeriapical PeriodontitisAnimalsCaspase 1FuransInterleukin-1betaMaleMiceMice, Inbred C57BLSulfonamidesSulfonesCaspase 1FuransIndenesInflammasomesInterleukin-1betaN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamideNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSulfonamidesSulfonesApical periodontitisEndodonticsNLRP3 inflammasomePeriapical lesionRodents

Identifiers

PMID38684528
PMCPMC11809525

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.