Evidence map›Paper›PMID 38684520›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Antineoplastic therapy is an independent risk factor for dental caries in childhood cancer patients: a retrospective cohort study.

Bruna C Longo, Isabel B Rohling, Pauline L M O E Silva, Hélvis E S Paz, Renato C V Casarin, Maria Daniela B Souza, Cléverson O Silva

Abstract read
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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Dental caries in childhood cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Review
  4. Impact of Oncologic Treatment on Health-Related Quality of Life of Children and Adolescents.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bruna C LongoDepartment of Dentistry, State University of Maringá (UEM), Av Mandacaru, 1550, Campus Universitário, Maringá, PR, Brazil.ORCID https://orcid.org/0000-0002-9498-3743
Isabel B RohlingDepartment of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, PR, Brazil.ORCID https://orcid.org/0000-0003-3385-5868
Pauline L M O E SilvaDepartment of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, PR, Brazil.ORCID https://orcid.org/0000-0002-6045-9556
Hélvis E S PazDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0002-0619-2547
Renato C V CasarinDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0003-1743-5855
Maria Daniela B SouzaDepartment of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, PR, Brazil.ORCID https://orcid.org/0000-0002-7238-060X
Cléverson O SilvaDepartment of Dentistry, State University of Maringá (UEM), Av Mandacaru, 1550, Campus Universitário, Maringá, PR, Brazil. prof.cleversonsilva@gmail.com.ORCID https://orcid.org/0000-0002-7103-9100

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the antineoplastic therapy (AT) as a risk factor for dental caries lesions independent of other risk factors such as income, family education, stimulated salivary flow rate, hygiene habits, frequency of sugar intake, and microbiota in childhood cancer (CC) patients.

methods72 individuals were divided into CC patients (n=36) and healthy individuals (control group - CT n=36). Demographic data, hygiene habits, frequency of sugar intake, CC type, and AT were collected. Stimulated salivary flow rate was measured and the presence and concentration of Streptococcus mutans were assessed using a real-time polymerase chain reaction (qPCR) technique. Clinical evaluations included plaque index (PI) and decayed-missing-filled-teeth index (dmft/DMFT). Descriptive statistics, T-test, Mann-Whitney test, chi-square test, Fisher's exact test, and two-way analysis of variance were used for data analysis (p<0.05).

resultsAt the time of oral evaluation, both groups exhibited similar ages with means of 12.0±3.9 years old for CC and 12.0±4.0 years old for CT patients. All CC patients underwent chemotherapy with nine also undergoing radiotherapy. Significant differences were observed between the groups in terms of color/race, income, family education, and hygiene habits. However, no statistically significant differences were found between groups regarding the frequency of sugar intake, stimulated salivary flow rate, or the concentration of Streptococcus mutans (qPCR technique). For clinical parameters, the DMF (CC:1.80, CT: 0.75), decayed (CC: 0.88, CT: 0.19), missing (CC: 0.25, CT:0), and PI (CC: 30.5%, CT: 22.6%) were higher in the CC group (p<0.05).

conclusionChildhood cancer (CC) patients undergoing antineoplastic therapy (AT) exhibit a higher prevalence of dental caries, regardless of income/education, frequency of sugar intake, stimulated salivary flow rate, and microbiota.

Indexed as

Antineoplastic AgentsDental CariesNeoplasmsStreptococcus mutansAdolescentCase-Control StudiesChildCohort StudiesDMF IndexFemaleHumansMaleOral HygieneRetrospective StudiesRisk FactorsSalivaAntineoplastic AgentsAntineoplastic protocolsCancer survivorsDental cariesOral health

Identifiers

PMID38684520

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.