Evidence map›Paper›PMID 38684455›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2024

HPLC-Based Automated Synthesis and Purification of Carbohydrates.

Gustavo A Kashiwagi, Laura Petrosilli, Samira Escopy, Luigi Lay, Keith J Stine, Cristina De Meo, Alexei V Demchenko

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Expediting Glycospace Exploration: Therapeutic Glycans via Automated Synthesis.Angewandte Chemie (International ed. in English) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gustavo A KashiwagiDepartment of Chemistry, Saint Louis University, 3501Laclede Ave, St. Louis, Missouri, 63103, USA.ORCID 0000-0002-1413-2317
Laura PetrosilliDepartment of Chemistry, Saint Louis University, 3501Laclede Ave, St. Louis, Missouri, 63103, USA.ORCID 0000-0002-8438-3277
Samira EscopyDepartment of Chemistry, Saint Louis University, 3501Laclede Ave, St. Louis, Missouri, 63103, USA.ORCID 0000-0002-1979-0036
Luigi LayDepartment of Chemistry, University of Milan, Via Golgi 19, Milan, 20133, Italy.ORCID 0000-0002-4774-4555
Keith J StineDepartment of Chemistry and Biochemistry, University of Missouri St. Louis, One University Boulevard, St. Louis, Missouri, 63121, USA.ORCID 0000-0003-0142-705X
Cristina De MeoDepartment of Chemistry, Southern Illinois University Edwardsville, 1 Hairpin Dr., Edwardsville, Illinois, 62025, USA.
Alexei V DemchenkoDepartment of Chemistry, Saint Louis University, 3501Laclede Ave, St. Louis, Missouri, 63103, USA.ORCID 0000-0003-3515-212X

Funding

Automation of the chemical synthesis of human milk oligosaccharidesR01GM111835 · NIGMS · SAINT LOUIS UNIVERSITY · PI DEMCHENKO, ALEXEI V · 2014 to 2023
$2.5M
Refinement and implementation of the automated oligosaccharide synthesizerU01GM120673 · NIGMS · UNIVERSITY OF MISSOURI-ST. LOUIS · PI DE MEO, CRISTINA, DEMCHENKO, ALEXEI V · 2016 to 2019
$2.2M
Methods and technologies for chemical synthesis of glycansR35GM152125 · NIGMS · SAINT LOUIS UNIVERSITY · PI ALEXEI V DEMCHENKO · 2024 to 2026
$1.2M
NIGMS NIH HHS GM111835, GM120673, GM152125NIGMS NIH HHS R01 GM111835NIGMS NIH HHS R35 GM152125NIGMS NIH HHS U01 GM120673
6 · The paper itself

Abstract

Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.

Indexed as

CarbohydratesOligosaccharidesAutomationChromatography, High Pressure LiquidGlycolipidsGlycopeptidesGlycosidesNucleosidesTemperatureCarbohydratesGlycolipidsGlycopeptidesGlycosidesNucleosidesOligosaccharidesAutomationGlycansGlycosylationHPLCSynthesis

Identifiers

PMID38684455
PMCPMC11586687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.