Evidence map›Paper›PMID 38684319›Full record

ArticleAJNR. American journal of neuroradiology2024

Sex-Specific Differences in Patients with

Sree Gongala, Jose A Garcia, Nisha Korakavi, Nirav Patil, Hamed Akbari, Andrew Sloan, Jill S Barnholtz-Sloan, Jessie Sun, Brent Griffith, Laila M Poisson and 16 more

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Sree GongalaFrom the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio.ORCID 0009-0006-6074-4871
Jose A GarciaCenter for Biomedical Image Computing and Analytics (CBICA) (J.A.G., C.D.), University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0009-0000-2703-0777
Nisha KorakaviFrom the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio.
Nirav PatilDepartment of Population and Quantitative Health Sciences (N.P.), Case Western Reserve University School of Medicine, Cleveland, Ohio.
Hamed AkbariDepartment of Bioengineering (H.A.), Santa Clara University, Santa Clara, California.ORCID 0000-0001-9786-3707
Andrew SloanNeuroscience Service line (A.Sloan), Department of Neurosurgery, Piedmont Health, Atlanta, Georgia.
Jill S Barnholtz-SloanCenter for Biomedical Informatics and Information Technology (J.S.B.-S.), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Jessie SunFrom the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio.
Brent GriffithDepartment of Radiology (B.G.), Henry Ford Health, Detroit, Michigan.ORCID 0000-0002-4184-1645
Laila M PoissonDepartment of Radiology (L.M.P.), Wayne State University School of Medicine Henry Ford, Detroit, Michigan.ORCID 0000-0002-3409-6536
Thomas C BoothSchool of Biomedical Engineering & Imaging Sciences (L.M.P.), King's College London, London, United Kingdom.ORCID 0000-0003-0984-3998
Rajan JainDepartments of Radiology and Neurosurgery (R.J., M.P.N.), New York University Langone Health, New York, New York.
Suyash MohanDepartment of Radiology (J.A.G., S.M., C.D.), Division of Neuroradiology at the University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-4025-115X
MacLean P NasrallaCenter for AI and Data Science for Integrated Diagnostics (C.D), at the University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-4861-0898
Spyridon BakasDivision of Computational Pathology (S.B.), Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana.ORCID 0000-0001-8734-6482
Charit TippareddyFrom the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio.
Josep PuigRadiology Department CDI (J.P.), Hospital Clinic of Barcelona, Barcelona, Spain.ORCID 0000-0003-2791-6599
Joshua D PalmerDepartment of Radiation Oncology and Neurosurgery (J.D.P.), The James Cancer Hospital at the Ohio State University Wexner Medical Center, Columbus, Ohio.
Wenyin ShiDepartment of Radiation Oncology (W.S.), Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Rivka R ColenDepartment of Radiology (R.R.C.), University of Pittsburgh, Pittsburgh, Pennsylvania.
Aristeidis SotirasDepartment of Radiology (A.Sotiras), WA University School of Medicine, St. Louis, Missouri.
Sung Soo AhnDepartment of Radiology (S.S.A., Y.W.P.), Section of Neuroradiology, Yonsei University Health System, Seoul, Republic of Korea.ORCID 0000-0002-0503-5558
Yae Won ParkDepartment of Radiology (S.S.A., Y.W.P.), Section of Neuroradiology, Yonsei University Health System, Seoul, Republic of Korea.ORCID 0000-0001-8907-5401
Christos DavatzikosCenter for Biomedical Image Computing and Analytics (CBICA) (J.A.G., C.D.), University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-1025-8561
Chaitra BadveFrom the Department of Radiology (S.G., N.K., J.S., C.T., C.B.), Case Western Reserve University School of Medicine, Cleveland, Ohio cab231@case.edu.ORCID 0000-0001-8547-8019
ReSPOND Consortium

Funding

Generalizable quantitative imaging and machine learning signatures in glioblastoma, for precision diagnostics and personalized treatment: the ReSPOND consortiumR01CA269948 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Christos Davatzikos · 2022 to 2026
$3.2M
Privacy-Aware Federated Learning for Breast Cancer Risk AssessmentU24CA279629 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI Spyridon Bakas · 2023 to 2026
$2.9M
NCI NIH HHS R01 CA269948NCI NIH HHS U24 CA279629
6 · The paper itself

Abstract

background and purposeUnderstanding sex-based differences in patients with glioblastoma is necessary for accurate personalized treatment planning to improve patient outcomes. Our purpose was to investigate sex-specific differences in molecular, clinical, and radiologic tumor parameters, as well as survival outcomes in patients with glioblastoma, isocitrate dehydrogenase-1 wild-type ( MATERIALS AND

methodsRetrospective data of 1832 patients with glioblastoma,

resultsGlioblastoma was diagnosed at a median age of 64 years in women compared with 61.9 years in men (false discovery rate [FDR] = 0.003). Men had a higher KPS (above 80) as compared with women (60.4% women versus 69.7% men, FDR = 0.044). Women had lower tumor volumes in enhancing (16.7 cm

conclusionsOur study demonstrates significant sex-based differences in clinical and radiologic tumor parameters of patients with glioblastoma. Sex is not an independent prognostic factor for survival outcomes and the tumor parameters influencing patient outcomes are identical for men and women.

Indexed as

Brain NeoplasmsIsocitrate DehydrogenaseFemaleGlioblastomaGliomaHumansMagnetic Resonance ImagingMaleMiddle AgedNeoplasm GradingRetrospective StudiesSex FactorsSurvival RateIDH1 protein, humanIsocitrate Dehydrogenase

Identifiers

PMID38684319
PMCPMC11392364

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.