Evidence map›Paper›PMID 38684260›Full record

Trial reportBMJ open2024

Maternal positional therapy for fetal growth and customised birth weight centile benefit in a Bayesian reanalysis of a double-blind, sham-controlled, randomised clinical trial.

Jerry Coleman, Sahibjot Grewal, Jane Warland, Sebastian Hobson, Kuan Liu, Allan Kember

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02379728 (A Maternal Device to Reduce the Risk of Stillbirth and Low Birth-Weight), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02379728 nacompletednot on this map

A Maternal Device to Reduce the Risk of Stillbirth and Low Birth-Weight

TypeinterventionalSponsorAllan KemberRan2015 to 2016Enrolled200ConditionsSleep, Pregnancy, Stillbirth, Infant, Low Birth WeightArmsPrenaBelt, Body Position Sensor, sham-PrenaBelt
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  2. A new frontier for positional therapy: obstetrics.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  3. Sleeping posture in pregnancy.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jerry ColemanObstetrics & Gynaecology, Korle Bu Teaching Hospital, Accra, Greater Accra, Ghana.
Sahibjot GrewalUniversity of Toronto Faculty of Medicine, Toronto, Ontario, Canada.
Jane WarlandThe University of Adelaide Faculty of Health and Medical Sciences, Adelaide, South Australia, Australia.
Sebastian HobsonDepartment of Obstetrics & Gynaecology, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.
Kuan LiuInstitute of Health Policy, Management, and Evaluation, University of Toronto Dalla Lana School of Public Health, Toronto, Ontario, Canada.
Allan KemberDepartment of Obstetrics & Gynaecology, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada allan.kember@mail.utoronto.ca.ORCID 0000-0002-9804-1040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo update the Ghana PrenaBelt Trial's (GPT) primary outcome data with the latest fetal growth standard and reanalyse it. To estimate the posterior probability, under various clinically relevant prior probabilities, of maternal nightly positional therapy (PT) throughout the third-trimester having a beneficial effect on customised birth weight centile (CBWC) using Bayesian analyses.

designA reanalysis of a double-blind, sham-controlled, randomised clinical trial.

settingA single, tertiary-level centre in Accra, Ghana.

participantsTwo-hundred participants entered, 181 completed and 167 were included in the final analysis. Participants were Ghanaian, healthy, aged 18-35 years, with low-risk, singleton pregnancies in their third-trimester, with Body Mass Index<35 kg/m

interventionsParticipants were randomised to receive treatment with either a PT or sham-PT device. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the CBWC using the latest Perinatal Institute, Gestation-Related Optimal Weight calculator. Using Bayesian methods, posterior probabilities of achieving a greater than 0%, 5% and 10% benefit in CBWC with PT were estimated. There was no secondary outcome.

resultsThe median (IQR) CBWC was 42% (15-71) and 28% (9-52) in the PT and sham-PT groups, respectively (difference 8.4%; 95% CI -0.30 to 18.2; p=0.06). For achieving a >0%, >5% and >10% gain in CBWC with PT, the posterior probabilities were highly probable, probable and unlikely, respectively, given a range of prior probabilities reflecting varying degrees of pre-existing enthusiasm and scepticism.

conclusionsMaternal nightly PT throughout the third-trimester did not have a statistically significant effect on CBWC on a frequentist analysis using the latest fetal growth standard. However, from a Bayesian analysis, clinicians can infer that PT is likely to benefit fetal growth but with a modest effect size. TRIAL REGISTRATION NUMBER: NCT02379728.

Indexed as

Bayes TheoremBirth WeightFetal DevelopmentAdolescentAdultDouble-Blind MethodFemaleGhanaHumansInfant, NewbornPregnancyPregnancy Trimester, ThirdYoung AdultFetal medicineMaternal medicineSLEEP MEDICINESTATISTICS & RESEARCH METHODS

Identifiers

PMID38684260
PMCPMC11057287

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.