Evidence map›Paper›PMID 38684219›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

Dynamic neuroreceptor positron emission tomography in non-anesthetized rats using point source based motion correction: A feasibility study with [

Tina Kroll, Alan Miranda, Alexandra Drechsel, Simone Beer, Markus Lang, Alexander Drzezga, Pedro Rosa-Neto, Jeroen Verhaeghe, David Elmenhorst, Andreas Bauer

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tina KrollInstitute of Neurosciences and Medicine (INM-2), Forschungszentrum Jülich GmbH, Germany.ORCID 0000-0002-5814-8601
Alan MirandaMolecular Imaging Center Antwerp, University of Antwerp, Belgium.ORCID 0000-0002-5381-015X
Alexandra DrechselInstitute of Neurosciences and Medicine (INM-2), Forschungszentrum Jülich GmbH, Germany.
Simone BeerInstitute of Neurosciences and Medicine (INM-2), Forschungszentrum Jülich GmbH, Germany.
Markus LangInstitute of Neurosciences and Medicine (INM-5), Forschungszentrum Jülich GmbH, Germany.
Alexander DrzezgaInstitute of Neurosciences and Medicine (INM-2), Forschungszentrum Jülich GmbH, Germany.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Canada.ORCID 0000-0001-9116-1376
Jeroen VerhaegheMolecular Imaging Center Antwerp, University of Antwerp, Belgium.
David ElmenhorstInstitute of Neurosciences and Medicine (INM-2), Forschungszentrum Jülich GmbH, Germany.
Andreas BauerInstitute of Neurosciences and Medicine (INM-2), Forschungszentrum Jülich GmbH, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To prevent motion artifacts in small animal positron emission tomography (PET), animals are routinely scanned under anesthesia or physical restraint. Both may potentially alter metabolism and neurochemistry. This study investigates the feasibility of fully awake acquisition and subsequent absolute quantification of dynamic brain PET data via pharmacokinetic modelling in moving rats using the glutamate 5 receptor radioligand [

Indexed as

BrainFeasibility StudiesPositron-Emission TomographyPyridinesAnesthesiaAnimalsCarbon RadioisotopesMaleMotionOximesRadiopharmaceuticalsRatsRats, Sprague-DawleyReceptor, Metabotropic Glutamate 5Reproducibility of ResultsWakefulness3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloximeCarbon RadioisotopesOximesPyridinesRadiopharmaceuticalsReceptor, Metabotropic Glutamate 5[11C]ABP688Awake imagingpoint source based motion correctionpositron emission tomographytest-retest

Identifiers

PMID38684219
PMCPMC11504418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.