Evidence map›Paper›PMID 38683994›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A time-resolved single-cell roadmap of the logic driving anterior neural crest diversification from neural border to migration stages.

Aleksandr Kotov, Subham Seal, Mansour Alkobtawi, Vincent Kappès, Sofia Medina Ruiz, Hugo Arbès, Richard M Harland, Leonid Peshkin, Anne H Monsoro-Burq

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Genetic architecture of craniofacial morphogenesis: roles ofFrontiers in cell and developmental biology · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aleksandr Kotov *Université Paris-Saclay, Département de Biologie, Faculté des Sciences d'Orsay, Signalisation Radiobiology and Cancer, CNRS UMR 3347, INSERM U1021, Orsay F-91405, France.ORCID 0000-0003-2935-4737
Subham Seal *Université Paris-Saclay, Département de Biologie, Faculté des Sciences d'Orsay, Signalisation Radiobiology and Cancer, CNRS UMR 3347, INSERM U1021, Orsay F-91405, France.ORCID 0000-0003-2590-2935
Mansour AlkobtawiUniversité Paris-Saclay, Département de Biologie, Faculté des Sciences d'Orsay, Signalisation Radiobiology and Cancer, CNRS UMR 3347, INSERM U1021, Orsay F-91405, France.
Vincent KappèsUniversité Paris-Saclay, Département de Biologie, Faculté des Sciences d'Orsay, Signalisation Radiobiology and Cancer, CNRS UMR 3347, INSERM U1021, Orsay F-91405, France.ORCID 0000-0001-6650-7937
Sofia Medina RuizMolecular and Cell Biology Department, Genetics, Genomics and Development Division, University of California Berkeley, CA 94720.
Hugo ArbèsUniversité Paris-Saclay, Département de Biologie, Faculté des Sciences d'Orsay, Signalisation Radiobiology and Cancer, CNRS UMR 3347, INSERM U1021, Orsay F-91405, France.ORCID 0000-0001-5718-6529
Richard M HarlandMolecular and Cell Biology Department, Genetics, Genomics and Development Division, University of California Berkeley, CA 94720.ORCID 0000-0001-8247-4880
Leonid PeshkinSystems Biology Division, Harvard Medical School, Boston, MA 02115.
Anne H Monsoro-BurqUniversité Paris-Saclay, Département de Biologie, Faculté des Sciences d'Orsay, Signalisation Radiobiology and Cancer, CNRS UMR 3347, INSERM U1021, Orsay F-91405, France.ORCID 0000-0003-2427-982X

Funding

Systems Analysis of cell type differentiation in Xenopus developmentR01HD073104 · NICHD · HARVARD MEDICAL SCHOOL · PI KIRSCHNER, MARC WALLACE, PESHKIN, LEON · 2012 to 2022
$6.7M
Gene Expression in Amphibian DevlopementR01GM042341 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARLAND, RICHARD M · 1988 to 2016
$5.7M
Gene Expression in Amphibian DevelopmentR35GM127069 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Richard M Harland · 2018 to 2026
$4.2M
XenCAT: Xenopus Single Cell AtlasR24OD031956 · OD · HARVARD MEDICAL SCHOOL · PI PESHKIN, LEON · 2022 to 2025
$3.5M
NICHD NIH HHS R01 HD073104NIGMS NIH HHS R01 GM042341NIGMS NIH HHS R35 GM127069NIH HHS R24 OD031956
6 · The paper itself

Abstract

Neural crest cells exemplify cellular diversification from a multipotent progenitor population. However, the full sequence of early molecular choices orchestrating the emergence of neural crest heterogeneity from the embryonic ectoderm remains elusive. Gene-regulatory-networks (GRN) govern early development and cell specification toward definitive neural crest. Here, we combine ultradense single-cell transcriptomes with machine-learning and large-scale transcriptomic and epigenomic experimental validation of selected trajectories, to provide the general principles and highlight specific features of the GRN underlying neural crest fate diversification from induction to early migration stages using

Indexed as

Neural CrestSingle-Cell AnalysisXenopus laevisAnimalsCell DifferentiationCell MovementEmbryo, NonmammalianEpithelial-Mesenchymal TransitionGastrulationGene Expression Regulation, DevelopmentalGene Regulatory NetworksNeural PlateNeurulationTranscriptomegene regulatory networksneural borderneural crestsingle-cell transcriptomesXenopus

Identifiers

PMID38683994
PMCPMC11087755

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.