ArticleProceedings of the National Academy of Sciences of the United States of America2024
Incomplete-penetrant hypertrophic cardiomyopathy
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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15citing papers in PubMed
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Who cites it
15 citing papers in PubMed.
- Immature and mature myocardium in the pathophysiology of hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026Review
- The E525K β-Myosin Mutation Causes Hypocontractility in Cardiomyocytes Without Altering Loaded Crossbridge Cycling.bioRxiv : the preprint server for biology · 2026Article
- The hypertrophic cardiomyopathy mutation G768R makes cardiac myosin a high duty ratio motor.bioRxiv : the preprint server for biology · 2026Article
- Beta-Adrenergic Stimulation andbioRxiv : the preprint server for biology · 2026Article
- The hypertrophic cardiomyopathy myosin variant G256E prolongs cardiac muscle relaxation via altered nucleotide handling.Communications chemistry · 2026Article
- Abnormal Lipid Signaling Characterizes Diastolic Dysfunction in Pediatric Cardiomyopathy.JACC. Basic to translational science · 2026Article
- High-Throughput Methods for Variant Functional Assessment in Cardiac Disease.Circulation. Genomic and precision medicine · 2026Review
- The G256E HCM mutation prolongs cardiac muscle relaxation via altered nucleotide handling.Research square · 2025Article
- Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically.Nature communications · 2025Article
- Knockout of the Staphylococcus aureus virulence gene sdrC promotes Myh7 expression to inhibit the progression of osteomyelitis.Journal of molecular histology · 2025Article
- Article
- Coronary microcirculation dysfunction causing ischemia with non-obstructive coronary arteries: a case report.Frontiers in cardiovascular medicine · 2025Article
- Metabolic remodeling and cardiac dysfunction in left ventricular noncompaction: Insights from the MYH7 Q315R model.PloS one · 2025Article
- Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy.The EMBO journal · 2024Review
- From amoeboid myosin to unique targeted medicines for a genetic cardiac disease.Frontiers in physiology · 2024Review
Corrections and comments
- Erratum issued
- Update of
Authors and funding
24 authors.
Soah Lee *Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-7613-592X
Alison S Vander Roest *Department of Pediatrics (Cardiology), Stanford University School of Medicine, Stanford, CA 94305.
Cheavar A Blair *Biological Engineering, University of California, Santa Barbara, CA 93106.
Kerry Kao *Department of Bioengineering, University of Washington School of Medicine and College of Engineering, Seattle, WA 98195.ORCID 0000-0001-7095-4836
Samantha B Bremner *Department of Bioengineering, University of Washington School of Medicine and College of Engineering, Seattle, WA 98195.ORCID 0000-0003-3465-0442
Matthew C Childers *Department of Bioengineering, University of Washington School of Medicine and College of Engineering, Seattle, WA 98195.ORCID 0000-0003-2440-9612
Divya Pathak *Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Paul HeinrichStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Daniel LeeStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Orlando ChirikianBiological Engineering, University of California, Santa Barbara, CA 93106.
Saffie E MohranDepartment of Bioengineering, University of Washington School of Medicine and College of Engineering, Seattle, WA 98195.ORCID 0000-0003-0728-9882
Brock RobertsAllen Institute for Cell Science, Seattle, WA 98109.
Jacqueline E SmithAllen Institute for Cell Science, Seattle, WA 98109.
James W JahngStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
David T PaikStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Joseph C WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-6068-8041
Ruwanthi N GunawardaneAllen Institute for Cell Science, Seattle, WA 98109.
Kathleen M Ruppel *Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
David L Mack *Department of Bioengineering, University of Washington School of Medicine and College of Engineering, Seattle, WA 98195.
Beth L Pruitt *Biological Engineering, University of California, Santa Barbara, CA 93106.ORCID 0000-0002-4861-2124
Michael Regnier *Department of Bioengineering, University of Washington School of Medicine and College of Engineering, Seattle, WA 98195.ORCID 0000-0001-5437-9851
Sean M Wu *Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-0000-3821
James A Spudich *Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-4324-4254
Daniel Bernstein *Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-7761-5853
Funding
MYOSIN MOVEMENT IN VITRO: MOLECULAR CHARACTERIZATIONR01GM033289 · NIGMS · STANFORD UNIVERSITY · PI SPUDICH, JAMES · 1985 to 2024
$13.6MFrom proteins to cells to tissues: A multi-scale assessment of biomechanical regulation by the myosin molecular motorRM1GM131981 · NIGMS · STANFORD UNIVERSITY · PI BERNSTEIN, DANIEL, MACK, DAVID LEE · 2019 to 2023
$10.3MBioengineering Cardiovascular Training Grant (BCTG)T32EB032787 · NIBIB · UNIVERSITY OF WASHINGTON · PI MICHAEL REGNIER, Ying Zheng · 2022 to 2026
$969kModeling myosin mechanobiology towards understanding the mechanisms of hypertrophic cardiomyopathyR00HL153679 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VANDER ROEST, ALISON SCHROER · 2023 to 2025
$851kModeling myosin mechanobiology towards understanding the mechanisms of hypertrophic cardiomyopathyK99HL153679 · NHLBI · STANFORD UNIVERSITY · PI VANDER ROEST, ALISON SCHROER · 2021 to 2022
$329kIdentifying Angiocrine Factors for Cardiomyocyte Maturation Using Single-Cell SequencingK99HL150216 · NHLBI · STANFORD UNIVERSITY · PI PAIK, DAVID T · 2020 to 2021
$325kThe Role of Sarcomeric Protein Alignment in Connexin 43 Localization at Gap JunctionF32HL142205 · NHLBI · STANFORD UNIVERSITY · PI LEE, SOAH · 2018 to 2020
$188kNHLBI NIH HHS F32 HL142205NHLBI NIH HHS K99 HL150216NHLBI NIH HHS K99 HL153679NHLBI NIH HHS R00 HL153679NIBIB NIH HHS T32 EB032787NIGMS NIH HHS R01 GM033289NIGMS NIH HHS RM1 GM131981NIH HHS 1K99HL153679NIH HHS K99 HL150216
Abstract
Determining the pathogenicity of hypertrophic cardiomyopathy-associated mutations in the β-myosin heavy chain (
Indexed as
Cardiac MyosinsCardiomyopathy, HypertrophicInduced Pluripotent Stem CellsMyocardial ContractionMyocytes, CardiacMyosin Heavy ChainsCell RespirationHumansMitochondriaMutationMyofibrilsCardiac MyosinsMYH7 protein, humanMyosin Heavy Chainsbiomechanicshypertrophic cardiomyopathyinduced pluripotent stem cellsMYH7
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.