ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Data-driven decomposition and staging of flortaucipir uptake in Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Visual versus quantitative tau-PET Braak staging in Alzheimer's disease using [European journal of nuclear medicine and molecular imaging · 2026Article
- Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- SPECT and PET imaging of Alzheimer's disease revisited: from biomarkers to artificial intelligence-based prediction.Annals of nuclear medicine · 2026Review
- A unified model for staging amyloid and tau pathology in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- Taming dimensionality in big neuroimaging data: Efficient orthonormal projective NMF via stochastic learning and data compression.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Revealing Cortical Spreading Pathway of Neuropathological Events by Neural Optimal Mass Transport.IEEE transactions on medical imaging · 2025Article
- Analyzing heterogeneity in Alzheimer disease using multimodal normative modeling on imaging-based ATN biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Tau Imaging: Use and Implementation in New Diagnostic and Therapeutic Paradigms for Alzheimer's Disease.Geriatrics (Basel, Switzerland) · 2025Review
- Data-driven decomposition and staging of flortaucipir uptake in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Comprehensive evaluation of AT(N) imaging biomarkers for predicting cognitive decline.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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11 authors.
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Abstract
introductionPrevious approaches pursuing in vivo staging of tau pathology in Alzheimer's disease (AD) have typically relied on neuropathologically defined criteria. In using predefined systems, these studies may miss spatial deposition patterns which are informative of disease progression.
methodsWe selected discovery (n = 418) and replication (n = 132) cohorts with flortaucipir imaging. Non-negative matrix factorization (NMF) was applied to learn tau covariance patterns and develop a tau staging system. Flortaucipir components were also validated by comparison with amyloid burden, gray matter loss, and the expression of AD-related genes.
resultsWe found eight flortaucipir covariance patterns which were reproducible and overlapped with relevant gene expression maps. Tau stages were associated with AD severity as indexed by dementia status and neuropsychological performance. Comparisons of flortaucipir uptake with amyloid and atrophy also supported our model of tau progression. DISCUSSION: Data-driven decomposition of flortaucipir uptake provides a novel framework for tau staging which complements existing systems. HIGHLIGHTS: NMF reveals patterns of tau deposition in AD. Data-driven staging of flortaucipir tracks AD severity. Learned flortaucipir patterns overlap with AD-related gene expression.
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