Evidence map›Paper›PMID 38683753›Full record

ArticleJournal of medicinal chemistry2024

Identification of Potent and Selective Inhibitors of

Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, Marcus Hull, Steven L Kelly, F Peter Guengerich, Galina I Lepesheva

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Silver(I)-NHC Complexes as Dual-Action Agents Against PathogenicInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tatiana Y HargroveDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
David C LambFaculty of Medicine, Health and Life Science, Swansea University, Swansea SA2 8PP, U.K.
Zdzislaw WawrzakSynchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States.
Marcus HullFaculty of Medicine, Health and Life Science, Swansea University, Swansea SA2 8PP, U.K.
Steven L KellyFaculty of Medicine, Health and Life Science, Swansea University, Swansea SA2 8PP, U.K.
F Peter GuengerichDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-7458-3048
Galina I LepeshevaDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-6975-1131

Funding

Structural Requirements for Sterol 14alpha-DemethylasesR01GM067871 · NIGMS · VANDERBILT UNIVERSITY · PI LEPESHEVA, GALINA I · 2004 to 2023
$7.2M
Metabolism of Carcinogens and Drugs by Human P450sR01GM118122 · NIGMS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2016 to 2023
$3.3M
NIGMS NIH HHS R01 GM067871NIGMS NIH HHS R01 GM118122
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

14-alpha Demethylase InhibitorsSterol 14-DemethylaseAcanthamoebaAcanthamoeba castellaniiAntiprotozoal AgentsCrystallography, X-RayModels, MolecularMolecular StructureStructure-Activity Relationship14-alpha Demethylase InhibitorsAntiprotozoal AgentsSterol 14-Demethylase

Identifiers

PMID38683753
PMCPMC11089504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.