Evidence map›Paper›PMID 38683635›Full record

SynthesisCannabis and cannabinoid research2024

Endocannabinoids and Stress-Related Neurospsychiatric Disorders: A Systematic Review and Meta-Analysis of Basal Concentrations and Response to Acute Psychosocial Stress.

Leah C Gowatch, Julia M Evanski, Samantha L Ely, Clara G Zundel, Amanpreet Bhogal, Carmen Carpenter, MacKenna M Shampine, Emilie O'Mara, Raegan Mazurka, Jeanne Barcelona and 2 more

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Cannabis and cannabinoid research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07123467 (Cannabidiol-Enhanced Cognitive Behavioral Therapy for Generalized Anxiety Disorder), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07123467 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Cannabidiol-Enhanced Cognitive Behavioral Therapy for Generalized Anxiety Disorder

TypeinterventionalSponsorWayne State UniversityRan2025 to 2027Enrolled90ConditionsGeneralized Anxiety Disorder (GAD), Anxiety DisordersArmsLow-Dose Cannabidiol, Placebo Matched to Moderate-Dose Cannabidiol, Moderate-Dose Cannabidiol, Placebo Matched to Low-Dose Cannabidiol
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Circulating endocannabinoids in children and adolescents: associations with anxiety and the impact of selective serotonin reuptake inhibitors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Research Review: What we have learned about the endocannabinoid system in developmental psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
  12. Review
  13. Understanding the Role of Endocannabinoids in Posttraumatic Stress Disorder.International journal of molecular sciences · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Leah C GowatchDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Julia M EvanskiNeuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, USA.
Samantha L ElyDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Clara G ZundelDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Amanpreet BhogalDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Carmen CarpenterDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
MacKenna M ShampineDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Emilie O'MaraDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Raegan MazurkaDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Jeanne BarcelonaCenter for Health and Community Impact, College of Education, Wayne State University, Detroit, Michigan, USA.
Leah M MayoHotchkiss Brain Institute and Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Hilary A MarusakDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.ORCID 0000-0002-0771-6795

Funding

Impact of ambient PM2.5 concentrations on fear extinction recall, frontolimbic circuitry, and anxiety in adolescentsF32MH133274 · NIMH · WAYNE STATE UNIVERSITY · PI ZUNDEL, CLARA · 2023 to 2025
$221k
NIMH NIH HHS F32 MH133274
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

EndocannabinoidsPolyunsaturated AlkamidesStress, PsychologicalArachidonic AcidsGlyceridesHumansStress Disorders, Post-TraumaticanandamideArachidonic AcidsEndocannabinoidsGlyceridesglyceryl 2-arachidonatePolyunsaturated Alkamides2-AG2-arachidonoylglycerolanandamideanxietydepressionMaastricht Acute Stress Testpost-traumatic stress disorderTrier Social Stress Task

Identifiers

PMID38683635
PMCPMC11535454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.