Evidence map›Paper›PMID 38683467›Full record

ArticleEJNMMI research2024

Radiosynthesis automation, non-human primate biodistribution and dosimetry of K

Yu-Peng Zhou, Moses Q Wilks, Maeva Dhaynaut, Nicolas J Guehl, Danielle R Vesper, Sung-Hyun Moon, Peter A Rice, Georges El Fakhri, Marc D Normandin, Pedro Brugarolas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yu-Peng Zhou *Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA.
Moses Q Wilks *Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA.
Maeva DhaynautDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA.
Nicolas J GuehlDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA.
Danielle R VesperDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA.
Sung-Hyun MoonDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA.
Peter A RiceDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA.
Georges El FakhriDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA.
Marc D NormandinDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA. marc.normandin@yale.edu.
Pedro BrugarolasDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Bulfinch 051, Boston, MA, 02114, USA. pbrugarolas@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-7455-2743
Massachusetts General Hospital · USYale University · USHarvard University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Marc David Normandin · 2017 to 2026
$14.8M
Can [18F]3F4AP Detect Brain Demyelination? Evaluation of Novel PET Tracer in Nonhuman Primates and HumansR01NS114066 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2020 to 2024
$1.8M
Super-Resolution Light Microscope at University of Arkansas for Medical SciencesS10OD018065 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI STORRIE, BRIAN · 2015 to 2015
$600k
Development of next generation of α2δ-1 PET tracers for neuroimagingK99EB033407 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, YU-PENG · 2022 to 2023
$182k
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS K99EB033407NIBIB NIH HHS P41 EB022544NIBIB NIH HHS P41EB022544NIH HHS S10 OD018065NINDS NIH HHS R01 NS114066NINDS NIH HHS R01NS114066
6 · The paper itself

Abstract

background4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [

methodsAutomated radiosynthesis was carried out using a GE TRACERlab FX-C Pro synthesis module. One male and one female adult rhesus macaques were used in the study. A high-resolution CT from cranial vertex to knee was acquired. PET data were collected using a dynamic acquisition protocol with four bed positions and 13 passes over a total scan time of ~ 150 min. Based on the CT and PET images, volumes of interest (VOIs) were manually drawn for selected organs. Non-decay corrected time-activity curves (TACs) were extracted for each VOI. Radiation dosimetry and effective dose were calculated from the integrated TACs using OLINDA software.

resultsFully automated radiosynthesis of [

conclusionA cGMP-compatible automated radiosynthesis of [

Indexed as

[11C]3MeO4APAutomationBiodistributioncGMPPET tracerRadiation dosimetryVoltage-gated potassium channel

Identifiers

PMID38683467
PMCPMC11058135
OpenAlexW4396515410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.