Evidence map›Paper›PMID 38683289›Full record

ArticleGeroScience2024

Increases in regional brain volume across two native South American male populations.

Nikhil N Chaudhari, Phoebe E Imms, Nahian F Chowdhury, Margaret Gatz, Benjamin C Trumble, Wendy J Mack, E Meng Law, M Linda Sutherland, James D Sutherland, Christopher J Rowan and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Physical activity mediates age differences in cognition among Tsimane forager-horticulturalists.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Nikhil N ChaudhariDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Phoebe E ImmsEthel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Nahian F ChowdhuryEthel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Margaret GatzCenter for Economic and Social Research, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA.
Benjamin C TrumbleCenter for Evolution & Medicine, School of Human Evolution and Social Change, School of Life Sciences, Arizona State University, Tempe, AZ, USA.
Wendy J MackDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
E Meng LawiBRAIN Research Laboratory, Departments of Neuroscience, Computer Systems and Electrical Engineering, Monash University, Melbourne, VIC, Australia.
M Linda SutherlandMemorialCare Health Systems, Fountain Valley, CA, USA.
James D SutherlandMemorialCare Health Systems, Fountain Valley, CA, USA.
Christopher J RowanRenown Institute for Heart and Vascular Health, Reno, NV, USA.
L Samuel WannDivision of Cardiology, University of New Mexico, Albuquerque, NM, USA.
Adel H AllamDepartment of Cardiology, School of Medicine, Al-Azhar University, Al Mikhaym Al Daem, Cairo, Egypt.
Randall C ThompsonSaint Luke's Mid America Heart Institute, University of Missouri, Kansas City, MO, USA.
David E MichalikDepartment of Pediatrics, School of Medicine, University of California, Irvine, Orange, CA, USA.
Michael MiyamotoDivision of Cardiology, Mission Heritage Medical Group, Providence Health, Mission Viejo, CA, USA.
Guido LombardiUniversidad Peruana Cayetano Heredia, Lima, Peru.
Daniel K CummingsDepartment of Anthropology, University of New Mexico, Albuquerque, NM, USA.
Edmond SeabrightDepartment of Anthropology, University of New Mexico, Albuquerque, NM, USA.
Sarah AlamiDepartment of Anthropology, University of New Mexico, Albuquerque, NM, USA.
Angela R GarciaCenter for Evolution & Medicine, School of Human Evolution and Social Change, School of Life Sciences, Arizona State University, Tempe, AZ, USA.
Daniel E RodriguezInstitute of Biomedical Research, San Simon University, Cochabamba, Bolivia.
Raul Quispe GutierrezTsimane Health and Life History Project, San Borja, Beni, Bolivia.
Adrian J CopajiraTsimane Health and Life History Project, San Borja, Beni, Bolivia.
Paul L HooperDepartment of Anthropology, University of New Mexico, Albuquerque, NM, USA.
Kenneth H BuetowCenter for Evolution & Medicine, School of Human Evolution and Social Change, School of Life Sciences, Arizona State University, Tempe, AZ, USA.
Jonathan StieglitzInstitute for Advanced Study in Toulouse, Toulouse 1 Capitol University, Toulouse, France.
Michael D GurvenDepartment of Anthropology, University of California, Santa Barbara, USA.
Gregory S ThomasMemorialCare Health Systems, Fountain Valley, CA, USA.
Hillard S KaplanEconomic Science Institute, Argyros School of Business and Economics, Chapman University, Orange, CA, USA.
Caleb E FinchEthel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Andrei IrimiaDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA. irimia@usc.edu.ORCID 0000-0002-9254-9388

Funding

Testing Hypothesized Pathways Linking Infection, Physical Activity, Apoe Genotype, And Biological Sex To Low Dementia Prevalence And Reduced Brain Atrophy In Two Native American PopulationsR01AG054442 · NIA · CHAPMAN UNIVERSITY · PI CALEB E FINCH, Margaret Gatz · 2022 to 2026
$15.2M
Brain atrophy, cognitive impairment and Alzheimer's in low CVD-risk populationRF1AG054442 · NIA · UNIVERSITY OF NEW MEXICO · PI FINCH, CALEB E, GURVEN, MICHAEL DOUGLAS · 2017 to 2020
$8.8M
Neurovascular calcification, Alzheimer’s disease and related dementias in two Native South American populationsRF1AG082201 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI IRIMIA, ANDREI · 2023 to 2023
$2.5M
National Science Board 1748282NIA NIH HHS R01 AG054442NIA NIH HHS RF1 AG054442NIA NIH HHS RF1AG054442NIA NIH HHS RF1AG082201
6 · The paper itself

Abstract

Industrialized environments, despite benefits such as higher levels of formal education and lower rates of infections, can also have pernicious impacts upon brain atrophy. Partly for this reason, comparing age-related brain volume trajectories between industrialized and non-industrialized populations can help to suggest lifestyle correlates of brain health. The Tsimane, indigenous to the Bolivian Amazon, derive their subsistence from foraging and horticulture and are physically active. The Moseten, a mixed-ethnicity farming population, are physically active but less than the Tsimane. Within both populations (N = 1024; age range = 46-83), we calculated regional brain volumes from computed tomography and compared their cross-sectional trends with age to those of UK Biobank (UKBB) participants (N = 19,973; same age range). Surprisingly among Tsimane and Moseten (T/M) males, some parietal and occipital structures mediating visuospatial abilities exhibit small but significant increases in regional volume with age. UKBB males exhibit a steeper negative trend of regional volume with age in frontal and temporal structures compared to T/M males. However, T/M females exhibit significantly steeper rates of brain volume decrease with age compared to UKBB females, particularly for some cerebro-cortical structures (e.g., left subparietal cortex). Across the three populations, observed trends exhibit no interhemispheric asymmetry. In conclusion, the age-related rate of regional brain volume change may differ by lifestyle and sex. The lack of brain volume reduction with age is not known to exist in other human population, highlighting the putative role of lifestyle in constraining regional brain atrophy and promoting elements of non-industrialized lifestyle like higher physical activity.

Indexed as

BrainIndians, South AmericanAgedAged, 80 and overAgingAtrophyBoliviaCross-Sectional StudiesFemaleHumansLife StyleMaleMiddle AgedOrgan SizeTomography, X-Ray ComputedBrain agingCortexNeurodegeneration

Identifiers

PMID38683289
PMCPMC11336037

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.