Evidence map›Paper›PMID 38683273›Full record

ArticleProbiotics and antimicrobial proteins2025

Lactiplantibacillus plantarum RS20D Alleviates Male Reproductive Toxicity Induced by Pubertal Exposure to Di-n-butyl Phthalate and Mono-n-butyl Phthalate.

Yuan-Ting Zhu, Xing-Jie Wang, Shu-Liang Liu, Jing-Hui Lai, Jian-Long Li, Qin Li, Kai-di Hu, Ai-Ping Liu, Yong Yang, Li He and 3 more

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuan-Ting Zhu *College of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Xing-Jie Wang *College of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Shu-Liang LiuCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China. lsliang999@163.com.
Jing-Hui LaiCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Jian-Long LiCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Qin LiCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Kai-di HuCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Ai-Ping LiuCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Yong YangCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Li HeCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Shu-Juan ChenCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Xiao-Lin AoCollege of Food Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, People's Republic of China.
Li-Kou ZouCollege of Resources, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People's Republic of China.

Funding

the National Natural Science Foundation of China Grant No. 31871770the Science & Technology Foundation of Sichuan Province, China Grant No. 2020YFN0133
6 · The paper itself

Abstract

Phthalate acid esters (PAEs) and their metabolites, such as di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP), are known to cause male reproductive damage. Lactiplantibacillus plantarum RS20D has demonstrated the ability to remove both DBP and MBP in vitro, suggesting its potential as a detoxifying agent against these compounds. This study aimed to investigate the protective effects of RS20D on DBP or MBP-induced male reproductive toxicity in adolescent rats. Oral administration of RS20D significantly mitigated the histological damage to the testes caused by MBP or DBP, restored sperm concentration, morphological abnormalities, and the proliferation index in MBP-exposed rats, and partially reversed spermatogenic damage in DBP-exposed rats. Furthermore, RS20D restored serum levels of estradiol (E2) and testosterone, and superoxide dismutase (SOD) activity in DBP-exposed rats, significantly increased testosterone levels in MBP-exposed rats, and restored copper (Cu) concentrations in the testes after exposure to DBP or MBP. Additionally, RS20D effectively modulated the intestinal microbiota in DBP-exposed rats and partially ameliorated dysbiosis induced by MBP, which may be associated with the alleviation of reproductive toxic effects induced by DBP or MBP. In conclusion, this study demonstrates that RS20D administration can alleviate male reproductive toxicity and gut dysbacteriosis induced by DBP or MBP exposure, providing a dietary strategy for the bioremediation of PAEs and their metabolites.

Indexed as

Dibutyl PhthalateLactiplantibacillus plantarumPhthalic AcidsProbioticsAnimalsGastrointestinal MicrobiomeMaleRatsRats, Sprague-DawleySpermatozoaTestisTestosteroneDibutyl Phthalatemonobutyl phthalatePhthalic AcidsTestosteroneIntestinal microbiotaLactiplantibacillus plantarumMale reproductive toxicityMonoester phthalatesPhthalate

Identifiers

PMID38683273

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.