ArticleCirculation2024
ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels.
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Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
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Who cites it
13 citing papers in PubMed.
- ABCG2 transporter: Structural and functional associations with gout (Review).International journal of molecular medicine · 2026Review
- CD157Stem cell reports · 2026Article
- Direct in vivo reprogramming to relieve tissue ischemia via induced vasculogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells.Nature cardiovascular research · 2025Article
- Targeting Diabetic Retinopathy with Human iPSC-Derived Vascular Reparative Cells in a Type 2 Diabetes Model.Cells · 2025Article
- Endothelial transdifferentiation of glioma stem cells: a literature review.Acta neuropathologica communications · 2025Review
- UHRF1 in endothelial cells is essential for angiogenesis and associated with the activation of pro-angiogenic signaling pathways and expression of endothelial genes.Angiogenesis · 2025Article
- APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells.Inflammation and regeneration · 2025Article
- Mechanism of disturbed endothelial cell function on angiogenesis following ischemic brain stroke (Review).Experimental and therapeutic medicine · 2025Review
- Immune-privileged cord blood-derived endothelial colony-forming cells: advancing immunomodulation and vascular regeneration.Angiogenesis · 2025Review
- Endothelial heterogeneity in bone marrow: insights across development, adult life and leukemia.Leukemia · 2025Review
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Authors and funding
28 authors.
Yang Lin *Division of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.ORCID 0000-0002-0709-2468
Chang-Hyun Gil *Department of Pediatrics, Herman B. Wells Center for Pediatric Research (Y. Lin, C.-H.G., K.B., E.G., N.P., S.C., W.C.S., M. Yoshimoto, M.C.Y.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0001-8323-5064
Kimihiko Banno *Department of Pediatrics, Herman B. Wells Center for Pediatric Research (Y. Lin, C.-H.G., K.B., E.G., N.P., S.C., W.C.S., M. Yoshimoto, M.C.Y.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0002-1458-0881
Masataka YokoyamaDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.
Matthew WingoDepartment of Cardiothoracic Surgery (M.W.), Weill Cornell Medicine, New York, NY.ORCID 0000-0002-4901-9605
Ellen GoDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research (Y. Lin, C.-H.G., K.B., E.G., N.P., S.C., W.C.S., M. Yoshimoto, M.C.Y.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0001-8234-3047
Nutan PrasainDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research (Y. Lin, C.-H.G., K.B., E.G., N.P., S.C., W.C.S., M. Yoshimoto, M.C.Y.), Indiana University School of Medicine, Indianapolis.
Ying LiuDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.ORCID 0000-0003-3672-9621
Takashi HatoMedicine (T.H.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0002-0446-6575
Hisamichi NaitoDepartment of Vascular Physiology, Kanazawa University School of Medicine, Japan (H.N., T.W.).ORCID 0000-0002-0750-1743
Taku WakabayashiDepartment of Vascular Physiology, Kanazawa University School of Medicine, Japan (H.N., T.W.).ORCID 0000-0003-2640-6079
Musia SominskaiaDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.
Meng GaoDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.
Kevin ChenDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.ORCID 0000-0003-1929-1146
Fuqiang GengDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.
Jesus Maria Gomez SalineroDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.ORCID 0000-0002-9024-2171
Sisi ChenDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research (Y. Lin, C.-H.G., K.B., E.G., N.P., S.C., W.C.S., M. Yoshimoto, M.C.Y.), Indiana University School of Medicine, Indianapolis.
W Christopher ShelleyDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research (Y. Lin, C.-H.G., K.B., E.G., N.P., S.C., W.C.S., M. Yoshimoto, M.C.Y.), Indiana University School of Medicine, Indianapolis.
Momoko YoshimotoDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research (Y. Lin, C.-H.G., K.B., E.G., N.P., S.C., W.C.S., M. Yoshimoto, M.C.Y.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0002-7272-6682
Sergio Li CalziDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute (S.L.C., M.B.G.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0001-8963-1519
Michael P MurphySurgery (C.-H.G., M.P.M.), Indiana University School of Medicine, Indianapolis.
Kyoji HorieDepartment of Physiology II, Nara Medical University, Kashihara, Nara, Japan (K.B., K.H.).ORCID 0000-0001-9036-8180
Maria B GrantDepartment of Ophthalmology, Eugene and Marilyn Glick Eye Institute (S.L.C., M.B.G.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0002-6470-0255
Ryan SchreinerDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.ORCID 0000-0002-7457-6606
David RedmondDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.ORCID 0000-0002-0983-8606
David P BasileAnatomy, Cell Biology & Physiology (D.P.B.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0003-4649-3464
Shahin RafiiDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine (Y. Lin, M. Yokoyama, Y. Liu, M.S., M.G., K.C., F.G., J.M.G.S., R.S., D.R., S.R.), Weill Cornell Medicine, New York, NY.ORCID 0000-0001-5605-1067
Mervin C YoderDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research (Y. Lin, C.-H.G., K.B., E.G., N.P., S.C., W.C.S., M. Yoshimoto, M.C.Y.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0003-4354-7631
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3MVisual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAWRENCE C SINCICH · 1985 to 2026
$16.9MProject-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7MNITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6MAdaptable tissue-specific endothelial cells for organ regenerationR35HL150809 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Shahin Rafii · 2020 to 2026
$7.1MEndothelial cell transplantation for multi-organ repair to counter radiation injuryU01AI138329 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI KIEM, HANS-PETER, RAFII, SHAHIN · 2018 to 2022
$3.3MNiche signals in HSC genesisRC2DK114777 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERNSTEIN, IRWIN D, RAFII, SHAHIN · 2017 to 2021
$3.3MMolecular Determinants of liver sinusoidal endothelial cells for hepatic regenerationR01DK136327 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Shahin Rafii · 2023 to 2026
$1.8MHuman Vertebral Body Mesenchymal Stromal Cells from Organ Donors For Limb Preservation in a Murine Model of Diabetic Hindlimb IschemiaR01HL171277 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Michael Patrick Murphy · 2024 to 2026
$1.4MBD FACSAria SystemS10OD012270 · OD · INDIANA UNIVERSITY INDIANAPOLIS · PI SROUR, EDWARD F · 2013 to 2013
$516kDifferent roles of fetal- and adult-derived IgA secreting cells against GI infectionR21AI178153 · NIAID · WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE · PI YOSHIMOTO, MOMOKO · 2023 to 2024
$432kNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA082709NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY012601NHLBI NIH HHS R01 HL171277NHLBI NIH HHS R35 HL150809NIAID NIH HHS R21 AI178153NIAID NIH HHS U01 AI138329NIDDK NIH HHS R01 DK136327NIDDK NIH HHS RC2 DK114777NIDDK NIH HHS U54 DK106846NIH HHS S10 OD012270
Abstract
backgroundMost organs are maintained lifelong by resident stem/progenitor cells. During development and regeneration, lineage-specific stem/progenitor cells can contribute to the growth or maintenance of different organs, whereas fully differentiated mature cells have less regenerative potential. However, it is unclear whether vascular endothelial cells (ECs) are also replenished by stem/progenitor cells with EC-repopulating potential residing in blood vessels. It has been reported recently that some EC populations possess higher clonal proliferative potential and vessel-forming capacity compared with mature ECs. Nevertheless, a marker to identify vascular clonal repopulating ECs (CRECs) in murine and human individuals is lacking, and, hence, the mechanism for the proliferative, self-renewal, and vessel-forming potential of CRECs is elusive.
methodsWe analyzed colony-forming, self-renewal, and vessel-forming potential of ABCG2 (ATP binding cassette subfamily G member 2)-expressing ECs in human umbilical vessels. To study the contribution of
resultsIn human and mouse vessels, ECs with higher
conclusionsThese results are the first to establish that a single prospective marker identifies CRECs in mice and human individuals, which holds promise to provide new cell therapies for repair of damaged vessels in patients with endothelial dysfunction.
Indexed as
ATP Binding Cassette Transporter, Subfamily G, Member 2AnimalsBlood VesselsCell LineageCell ProliferationEndothelial CellsHumansHuman Umbilical Vein Endothelial CellsMiceMice, TransgenicMyocardial InfarctionNeoplasm ProteinsNeovascularization, PhysiologicRegenerationABCG2 protein, humanAbcg2 protein, mouseATP Binding Cassette Transporter, Subfamily G, Member 2Neoplasm Proteinsangiogenesisblood vesselsdevelopmental biologyendothelial cells
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