Evidence map›Paper›PMID 38682243›Full record

Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2024

Pioglitazone does not enhance exogenous glucose oxidation or metabolic clearance rate during aerobic exercise in men under acute high-altitude exposure.

Lee M Margolis, Marques A Wilson, Devin J Drummer, Christopher T Carrigan, Nancy E Murphy, Jillian T Allen, M Alan Dawson, Christos S Mantzoros, Andrew J Young, Stefan M Pasiakos

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lee M MargolisUnited States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.ORCID 0000-0002-0652-1304
Marques A WilsonUnited States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.
Devin J DrummerUnited States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.ORCID 0000-0002-8003-562X
Christopher T CarriganUnited States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.
Nancy E MurphyUnited States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.
Jillian T AllenUnited States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.
M Alan DawsonUnited States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.
Christos S MantzorosDepartment of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States.
Andrew J YoungUnited States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.ORCID 0000-0002-9019-128X
Stefan M PasiakosOffice of Dietary Supplements, National Institutes of Health, Bethesda, Maryland, United States.

Funding

USAMRDC N/A
6 · The paper itself

Abstract

Insulin insensitivity decreases exogenous glucose oxidation and metabolic clearance rate (MCR) during aerobic exercise in unacclimatized lowlanders at high altitude (HA). Whether use of an oral insulin sensitizer before acute HA exposure enhances exogenous glucose oxidation is unclear. This study investigated the impact of pioglitazone (PIO) on exogenous glucose oxidation and glucose turnover compared with placebo (PLA) during aerobic exercise at HA. With the use of a randomized crossover design, native lowlanders (

Indexed as

AltitudeCross-Over StudiesExerciseGlucoseHypoglycemic AgentsOxidation-ReductionPioglitazoneAdultBlood GlucoseHumansInsulinMaleMetabolic Clearance RateYoung AdultBlood GlucoseGlucoseHypoglycemic AgentsInsulinPioglitazoneglycogenolysishypoxiainsulin resistancesubstrate oxidation

Identifiers

PMID38682243
PMCPMC11381008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.