Evidence map›Paper›PMID 38682238›Full record

Trial reportAmerican journal of physiology. Cell physiology2024

Acute effects of a ketone monoester, whey protein, or their coingestion on mTOR trafficking and protein-protein colocalization in human skeletal muscle.

Sarkis J Hannaian, Jamie Lov, Zacharie Cheng-Boivin, Sidney Abou Sawan, Nathan Hodson, Benoit J Gentil, José A Morais, Tyler A Churchward-Venne

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarkis J HannaianDepartment of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-6925-8152
Jamie LovDepartment of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada.
Zacharie Cheng-BoivinDepartment of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada.
Sidney Abou SawanIovate Health Sciences International, Oakville, Ontario, Canada.
Nathan HodsonDepartment of Sport and Exercise Science, Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom.
Benoit J GentilDepartment of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada.
José A MoraisDepartment of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada.
Tyler A Churchward-VenneDepartment of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-6006-5461

Funding

Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)McGill Sylvan Adams Sports Science Institute
6 · The paper itself

Abstract

We recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their coingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their coingestion on mechanistic target of rapamycin (mTOR)-related protein-protein colocalization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 36 healthy recreationally active young males (age: 24.2 ± 4.1 yr) ingested either:

Indexed as

Muscle, SkeletalProtein TransportTOR Serine-Threonine KinasesWhey Proteins3-Hydroxybutyric AcidAdultDouble-Blind MethodHumansKetonesMaleMuscle ProteinsPostprandial PeriodYoung Adult3-Hydroxybutyric AcidKetonesMTOR protein, humanMuscle ProteinsTOR Serine-Threonine KinasesWhey Proteinsimmunofluorescenceketone bodiesRhebTSC2β-hydroxybutyrate

Identifiers

PMID38682238
PMCPMC11371313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.