Evidence map›Paper›PMID 38682230›Full record

ArticleJournal of integrative neuroscience2024

Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease.

Sydney G Hillan, Anders J Asp, Leena B Pramanik, Aarushi A Mukerjee, Carter B Mulder, Wendy D Lujan, Jodi L Silvernail, Su-Youne Chang, Suelen L Boschen, J Luis Lujan

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Article in Journal of integrative neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Sydney G HillanMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Anders J AspDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.
Leena B PramanikMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Aarushi A MukerjeeDepartment of Neurologic Surgery, Mayo Clinic, Jacksonville, FL 32224, USA.
Carter B MulderDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN 55454, USA.
Wendy D LujanDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Jodi L SilvernailDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Su-Youne ChangDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Suelen L BoschenDepartment of Neurologic Surgery, Mayo Clinic, Jacksonville, FL 32224, USA.
J Luis LujanDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.

Funding

In Vivo Fluorescent Microscopy Analysis of Motor Cortex Activation by STN DBSR01NS107336 · NINDS · MAYO CLINIC ROCHESTER · PI LUJAN, LUIS · 2018 to 2020
$1.1M
NINDS NIH HHS R01 NS107336
6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for the motor symptoms of Parkinson's disease (PD). While PD is primarily characterized by motor symptoms such as tremor, rigidity, and bradykinesia, it also involves a range of non-motor symptoms, and anxiety is one of the most common. The relationship between PD and anxiety is complex and can be a result of both pathological neural changes and the psychological and emotional impacts of living with a chronic progressive condition. Managing anxiety in PD is critical for improving the patients' quality of life. However, patients undergoing STN DBS can occasionally experience increased anxiety.

methodsThis study investigates changes in risk-avoidant behavior following STN DBS in a pre-motor animal model of PD under chronic and acute unilateral high frequency stimulation.

resultsNo significant changes in risk-avoidant behaviors were observed in rats who underwent STN DBS compared with sham stimulation controls. Chronic stimulation prevented sensitization in the elevated zero maze.

conclusionsThese results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.

Indexed as

Deep Brain StimulationDisease Models, AnimalOxidopamineSubthalamic NucleusAnimalsAnxietyAvoidance LearningBehavior, AnimalMaleParkinson DiseaseParkinsonian DisordersRatsRats, Sprague-DawleyOxidopamine6-hydroxydopaminedeep brain stimulationParkinson's diseaserisk-avoidancesubthalamic nucleus

Identifiers

PMID38682230
PMCPMC11238881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.