Evidence map›Paper›PMID 38681877›Full record

ArticleJournal of emergencies, trauma, and shock

Seizure Prophylaxis in Young Patients Following Traumatic Brain Injury.

Ahmed Abdel-Aziz Bahey, Talat Chughtai, Ayman El-Menyar, Vishwajit Verma, Gustav Strandvik, Mohammad Asim, Rafael Consunji, Basil Younis, Ashok Parchani, Sandro Rizoli and 1 more

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Article in Journal of emergencies, trauma, and shock. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ahmed Abdel-Aziz BaheyDepartment of Pharmacy, Clinical Pharmacy, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.
Talat ChughtaiDepartment of Surgery, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.
Ayman El-MenyarDepartment of Surgery, Clinical Research, Trauma and Vascular Surgery, Hamad General Hospital, Doha, Qatar.
Vishwajit VermaDepartment of Surgery, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.
Gustav StrandvikDepartment of Surgery, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.
Mohammad AsimDepartment of Surgery, Clinical Research, Trauma and Vascular Surgery, Hamad General Hospital, Doha, Qatar.
Rafael ConsunjiDepartment of Surgery, Injury Prevention, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.
Basil YounisDepartment of Surgery, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.
Ashok ParchaniDepartment of Surgery, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.
Sandro RizoliDepartment of Surgery, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.
Hassan Al-ThaniDepartment of Surgery, Trauma Surgery Section, Hamad General Hospital, Doha, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Phenytoin is one of the commonly used anti.seizure medications in nontraumatic seizures. However, its utility and safety in young patients with traumatic brain injury (TBI) for the prevention of early-onset seizures (EOS) are debatable. We sought to explore the use of phenytoin as a seizure prophylaxis following TBI. We hypothesized that administering phenytoin is not effective in preventing EOS after TBI. Methods: This was a retrospective observational study conducted on adult TBI patients. EOS was defined as a witnessed seizure within a week postinjury. Data were compared as phenytoin versus no-phenytoin use, EOS versus no-EOS, and among TBI severity groups. Results: During 1 year, 639 TBI patients were included with a mean age of 32 years; of them, 183 received phenytoin as seizure prophylaxis, and 453 received no prophylaxis medication. EOS was documented in 13 (2.0%) patients who received phenytoin, and none had EOS among the nonphenytoin group. The phenytoin group was more likely to have a higher Marshall Score ( Conclusions: In this study, the prophylactic use of phenytoin in TBI was ineffective in preventing EOS. Large-scale matched studies and well-defined hospital protocols are needed for the proper utility of phenytoin post-TBI.

Indexed as

Brain injuryearly onsetepilepsyphenytoinseizuretrauma

Identifiers

PMID38681877
PMCPMC11044991

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.